60849 20200221144320.0 doi 10.1016/j.jbiomech.2016.01.043 sideral 98262 ART-2016-98262 eng Waffenschmidt, T. Towards the modelling of ageing and atherosclerosis effects in ApoE-/- mice aortic tissue 2016 Access copy available to the general public Unrestricted The goal of this work consists in a quantitative analysis and constitutive modelling of ageing processes associated to plaque formation in mice arteries. Reliable information on the characteristic evolution of pressure–stretch curves due to the ageing effects is extracted from previous inflation test experiments. Furthermore, characteristic age-dependent material parameters are identified on the basis of a continuum-mechanics-based parameter optimisation technique. The results indicate that the aorta-stiffness of the healthy control mice remains basically constant irrespective of the diet-time and age. In contrast, significant differences exist within the material response and in consequence within the material parameters between the ApoE-/- and the control mice as well as for the different locations over the aorta which is underlined by our experimental observations. With regard to the temporal evolution of the material parameters, we observe that the material parameters for the ApoE-/- mice aortas exhibit a saturation-type increase with respect to age. info:eu-repo/grantAgreement/ES/DGA/T88 info:eu-repo/grantAgreement/ES/MINECO/DPI2013-44391 info:eu-repo/grantAgreement/ES/MINECO/PRI-AIBDE-2011-1216 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 2.664 2016 ENGINEERING, BIOMEDICAL 25 / 77 = 0.325 2016 Q2 T1 BIOPHYSICS 32 / 73 = 0.438 2016 Q2 T2 1.242 2016 Biomedical Engineering 2016 Q1 Biophysics 2016 Q1 Sports Science 2016 Q1 Rehabilitation 2016 Q1 Orthopedics and Sports Medicine 2016 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0002-8503-9291 Cilla, M. Sáez, P. Pérez, M.M. (orcid)0000-0002-8375-0354 Martínez, M.A. Universidad de Zaragoza Menzel, A. (orcid)0000-0002-0664-5024 Peña, E. Universidad de Zaragoza 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 49, 12 (2016), 2390-2397 J. biomech. Journal of Biomechanics 0021-9290 454894 http://zaguan.unizar.es/record/60849/files/texto_completo.pdf Postprint 77021 http://zaguan.unizar.es/record/60849/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:60849 articulos driver 2020-02-21-13:41:21 ARTICLE