doi:10.1073/pnas.1322651111engTimko, B.P.Arruebo, M.Shankarappa, S.A.McAlvin, J.B.Okonkwo, O.S.Mizrahi, B.Stefanescu, C.F.Gomez, L.Zhu, J.Zhu, A.Santamaria, J.Langer, R.Kohane, D.S.Near-infrared-actuated devices for remotely controlled drug deliveryART-2014-85449A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage to desired effect, with a consequent minimization of toxicity, and could obviate repeated drug administrations or device implantations, enhancing patient compliance. It should exhibit low off-state leakage to minimize basal effects, and tunable on-state release profiles that could be adjusted from pulsatile to sustained in real time. Despite the clear clinical need for a device that meets these criteria, none has been reported to date to our knowledge. To address this deficiency, we developed an implantable reservoir capped by a nanocomposite membrane whose permeability was modulated by irradiation with a near-infrared laser. Irradiated devices could exhibit sustained on-state drug release for at least 3 h, and could reproducibly deliver short pulses over at least 10 cycles, with an on/off ratio of 30. Devices containing aspart, a fast-acting insulin analog, could achieve glycemic control after s.c. implantation in diabetic rats, with reproducible dosing controlled by the intensity and timing of irradiation over a 2-wk period. These devices can be loaded with a wide range of drug types, and therefore represent a platform technology that might be used to address a wide variety of clinical indications.2014http://zaguan.unizar.es/record/6087410.1073/pnas.1322651111http://zaguan.unizar.es/record/60874oai:zaguan.unizar.es:60874Proceedings of the National Academy of Sciences 111, 4 (2014), 1349-1354byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess