60874 20170504082928.0 doi 10.1073/pnas.1322651111 sideral 85449 ART-2014-85449 eng Timko, B.P. Near-infrared-actuated devices for remotely controlled drug delivery 2014 Access copy available to the general public Unrestricted A reservoir that could be remotely triggered to release a drug would enable the patient or physician to achieve on-demand, reproducible, repeated, and tunable dosing. Such a device would allow precise adjustment of dosage to desired effect, with a consequent minimization of toxicity, and could obviate repeated drug administrations or device implantations, enhancing patient compliance. It should exhibit low off-state leakage to minimize basal effects, and tunable on-state release profiles that could be adjusted from pulsatile to sustained in real time. Despite the clear clinical need for a device that meets these criteria, none has been reported to date to our knowledge. To address this deficiency, we developed an implantable reservoir capped by a nanocomposite membrane whose permeability was modulated by irradiation with a near-infrared laser. Irradiated devices could exhibit sustained on-state drug release for at least 3 h, and could reproducibly deliver short pulses over at least 10 cycles, with an on/off ratio of 30. Devices containing aspart, a fast-acting insulin analog, could achieve glycemic control after s.c. implantation in diabetic rats, with reproducible dosing controlled by the intensity and timing of irradiation over a 2-wk period. These devices can be loaded with a wide range of drug types, and therefore represent a platform technology that might be used to address a wide variety of clinical indications. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 9.674 2014 MULTIDISCIPLINARY SCIENCES 4 / 57 = 0.07 2014 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Arruebo, M. Shankarappa, S.A. McAlvin, J.B. Okonkwo, O.S. Mizrahi, B. Stefanescu, C.F. Gomez, L. Zhu, J. Zhu, A. (orcid)0000-0002-8701-9745 Santamaria, J. Universidad de Zaragoza Langer, R. Kohane, D.S. 5005 555 Universidad de Zaragoza Departamento de Ingeniería Química y Tecnologías del Medio Ambiente Ingeniería Química 111, 4 (2014), 1349-1354 Proc. Natl. Acad. Sci. Proceedings of the National Academy of Sciences 0027-8424 1351847 http://zaguan.unizar.es/record/60874/files/texto_completo.pdf Versión publicada 145356 http://zaguan.unizar.es/record/60874/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:60874 articulos driver 2017-05-04-08:24:14 ARTICLE