000060949 001__ 60949
000060949 005__ 20200221144341.0
000060949 0247_ $$2doi$$a10.1002/lt.24474
000060949 0248_ $$2sideral$$a94416
000060949 037__ $$aART-2016-94416
000060949 041__ $$aeng
000060949 100__ $$0(orcid)0000-0001-6033-2216$$aAraiz, Juan José$$uUniversidad de Zaragoza
000060949 245__ $$aIntention-to-treat survival analysis of HCV/HIV co-infected liver transplant: Is it the waiting list?
000060949 260__ $$c2016
000060949 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060949 5203_ $$aIn human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients, the accelerated severity of liver disease, associated comorbidities, and mortality on the waiting list could change the possibility and results of liver transplantation (LT). Intention-to-treat survival analysis (ITTA) can accurately estimate the applicability and efficacy of LT. The primary objective of this study was to compare the survival of patients with HCV with and without HIV infection. We analyzed a cohort of 199 patients with HCV infection enrolled for LT between 1998 and 2015; 17 were also infected with HIV. The patients with HCV/HIV coinfection had higher mortality on the waiting list than those with HCV monoinfection (35.3% versus 4.6%; P¿<¿0.001). ITTA at 1, 3, and 4 years was 75%, 64%, and 57% for HCV monoinfection and 52%, 47%, and 39% for HCV/HIV coinfection, respectively (Wilcoxon test P¿<¿0.05). The ITTA at 1, 3, 6, and 12 months was 96%, 91%, 87%, and 75% for HCV monoinfection and 76%, 70%, 64%, and 52% for HCV/HIV coinfection, respectively (log-rank P¿<¿0.05; Wilcoxon test P¿<¿0.01). A Cox regression analysis was carried out including all variables with predictive value in the univariate analysis, showing that only donor age¿>¿70 years (hazard ratio [HR]¿=¿3.12; P¿<¿0.05), United Network for Organ Sharing status 1 (HR¿=¿10.1; P¿<¿0.01), Model for End-Stage Liver Disease (HR¿=¿1.13; P¿<¿0.001), and HIV coinfection (HR¿=¿2.65; P¿<¿0.05) had independent negative predictive value for survival. In conclusion, our study indicates that HIV coinfection is a factor in mortality prior to transplantation and associated with higher mortality on the waiting list.
000060949 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000060949 590__ $$a3.91$$b2016
000060949 591__ $$aGASTROENTEROLOGY & HEPATOLOGY$$b19 / 79 = 0.241$$c2016$$dQ1$$eT1
000060949 591__ $$aTRANSPLANTATION$$b6 / 25 = 0.24$$c2016$$dQ1$$eT1
000060949 591__ $$aSURGERY$$b20 / 196 = 0.102$$c2016$$dQ1$$eT1
000060949 592__ $$a1.635$$b2016
000060949 593__ $$aHepatology$$c2016$$dQ1
000060949 593__ $$aTransplantation$$c2016$$dQ1
000060949 593__ $$aSurgery$$c2016$$dQ1
000060949 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000060949 700__ $$0(orcid)0000-0002-7119-2244$$aSerrano, Trinidad$$uUniversidad de Zaragoza
000060949 700__ $$0(orcid)0000-0002-8275-7191$$aGarcía Gil, Agustín$$uUniversidad de Zaragoza
000060949 700__ $$aLacruz, Elena
000060949 700__ $$0(orcid)0000-0003-4672-8083$$aLorente, Sara$$uUniversidad de Zaragoza
000060949 700__ $$aSanchez, Jose Ignacio
000060949 700__ $$0(orcid)0000-0002-4563-9954$$aSuarez, Miguel Angel$$uUniversidad de Zaragoza
000060949 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000060949 7102_ $$11004$$2090$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Cirugía
000060949 773__ $$g22, 9 (2016), 1186-1196$$pLiver transplant.$$tLIVER TRANSPLANTATION$$x1527-6465
000060949 8564_ $$s1737978$$uhttps://zaguan.unizar.es/record/60949/files/texto_completo.pdf$$yPostprint
000060949 8564_ $$s52000$$uhttps://zaguan.unizar.es/record/60949/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000060949 909CO $$ooai:zaguan.unizar.es:60949$$particulos$$pdriver
000060949 951__ $$a2020-02-21-13:50:06
000060949 980__ $$aARTICLE