000060967 001__ 60967
000060967 005__ 20210222080315.0
000060967 0247_ $$2doi$$a10.3390/nu9030308
000060967 0248_ $$2sideral$$a98504
000060967 037__ $$aART-2017-98504
000060967 041__ $$aeng
000060967 100__ $$0(orcid)0000-0003-0076-3529$$aGomollón, F.$$uUniversidad de Zaragoza
000060967 245__ $$aOral cyanocobalamin is effective in the treatment of vitamin B12 deficiency in crohn’s disease
000060967 260__ $$c2017
000060967 5060_ $$aAccess copy available to the general public$$fUnrestricted
000060967 5203_ $$aCobalamin deficiency is common in patients with Crohn’s disease (CD). Intramuscular cobalamin continues to be the standard therapy for the deficiency and maintenance treatment in these patients, although oral route has been demonstrated to be effective in other pathologies with impaired absorption. Our aims were to evaluate the efficacy of oral therapy in the treatment of cobalamin deficiency and in long-term maintenance in patients with Crohn’s disease. We performed a multicenter retrospective cohort study that included 94 patients with Crohn’s disease and cobalamin deficiency. Seventy-six patients had B12 deficiency and 94.7% of them normalized their cobalamin levels with oral treatment. The most used dose was 1 mg/day, but there were no significant differences in treatment effectiveness depending on the dose used (=1 mg/24 h vs. <1 mg/24 h). Eighty-two patients had previous documented B12 deficiency and were treated with oral B12 to maintain their correct cobalamin levels. After a mean follow-up of 3 years, the oral route was effective as maintenance treatment in 81.7% of patients. A lack of treatment adherence was admitted by 46.6% of patients in who the oral route failed. In conclusion, our study shows that oral cyanocobalamin provides effective acute and maintenance treatment for vitamin B12 deficiency caused by CD with or without ileum resection.
000060967 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000060967 590__ $$a4.196$$b2017
000060967 591__ $$aNUTRITION & DIETETICS$$b18 / 81 = 0.222$$c2017$$dQ1$$eT1
000060967 592__ $$a1.557$$b2017
000060967 593__ $$aNutrition and Dietetics$$c2017$$dQ1
000060967 593__ $$aFood Science$$c2017$$dQ1
000060967 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000060967 700__ $$0(orcid)0000-0002-3545-2707$$aGargallo, C. J.
000060967 700__ $$aMuñoz, J. F.
000060967 700__ $$0(orcid)0000-0002-7605-3534$$aVicente, R.
000060967 700__ $$aLue, A.
000060967 700__ $$aMir, A.
000060967 700__ $$aGarcía-Alvarado, M.
000060967 700__ $$aGracia Ruiz, M.
000060967 700__ $$0(orcid)0000-0003-3970-5457$$aGarcía-López, S.$$uUniversidad de Zaragoza
000060967 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000060967 773__ $$g9, 3 (2017), 308 [11 pp.]$$pNUTRIENTS$$tNutrients$$x2072-6643
000060967 8564_ $$s453840$$uhttps://zaguan.unizar.es/record/60967/files/texto_completo.pdf$$yVersión publicada
000060967 8564_ $$s109029$$uhttps://zaguan.unizar.es/record/60967/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000060967 909CO $$ooai:zaguan.unizar.es:60967$$particulos$$pdriver
000060967 951__ $$a2021-02-22-07:51:26
000060967 980__ $$aARTICLE