000060991 001__ 60991 000060991 005__ 20190709135532.0 000060991 0247_ $$2doi$$a10.3390/molecules22040574 000060991 0248_ $$2sideral$$a98568 000060991 037__ $$aART-2017-98568 000060991 041__ $$aeng 000060991 100__ $$aOrtiz, R. 000060991 245__ $$aDirect substitution of alcohols in pure water by brønsted acid catalysis 000060991 260__ $$c2017 000060991 5060_ $$aAccess copy available to the general public$$fUnrestricted 000060991 5203_ $$aWith the increasing concern for sustainability, the use of environmentally friendly media to perform chemical processes has attracted the attention of many research groups. Among them, the use of water, as the unique solvent for reactions, is currently an active area of research. One process of particular interest is the direct nucleophilic substitution of an alcohol avoiding its preliminary transformation into a good leaving group, since one of the by-products in this approach would be water. The direct substitution of allylic, benzylic, and tertiary alcohols has been achieved through SN1-Type reactions with catalytic amounts of Brønsted or Lewis acids; however, organic solvents are often required. In this review, the pioneering SN1 approaches performed in pure water and in the absence of a metal based Lewis acid are compiled and discussed. 000060991 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E104 000060991 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000060991 590__ $$a3.098$$b2017 000060991 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b68 / 171 = 0.398$$c2017$$dQ2$$eT2 000060991 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b133 / 292 = 0.455$$c2017$$dQ2$$eT2 000060991 592__ $$a0.855$$b2017 000060991 593__ $$aAnalytical Chemistry$$c2017$$dQ1 000060991 593__ $$aPharmaceutical Science$$c2017$$dQ1 000060991 593__ $$aChemistry (miscellaneous)$$c2017$$dQ1 000060991 593__ $$aOrganic Chemistry$$c2017$$dQ2 000060991 593__ $$aPhysical and Theoretical Chemistry$$c2017$$dQ2 000060991 593__ $$aDrug Discovery$$c2017$$dQ2 000060991 593__ $$aMedicine (miscellaneous)$$c2017$$dQ2 000060991 593__ $$aMolecular Medicine$$c2017$$dQ3 000060991 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion 000060991 700__ $$0(orcid)0000-0002-5244-9569$$aPérez Herrera, R.$$uUniversidad de Zaragoza 000060991 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica 000060991 773__ $$g22, 4 (2017), 574 [12 pp.]$$pMolecules$$tMolecules$$x1420-3049 000060991 8564_ $$s1221527$$uhttps://zaguan.unizar.es/record/60991/files/texto_completo.pdf$$yVersión publicada 000060991 8564_ $$s97351$$uhttps://zaguan.unizar.es/record/60991/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000060991 909CO $$ooai:zaguan.unizar.es:60991$$particulos$$pdriver 000060991 951__ $$a2019-07-09-12:02:57 000060991 980__ $$aARTICLE