A simple dilute-and-shoot approach for the determination of ultra-trace levels of arsenic in biological fluids via ICP-MS using CH3F/He as a reaction gas
Resumen: The performance of a mixture of CH3F/He (1/9) as a reaction gas for the determination of As in biological fluids using a quadrupole ICP-MS instrument has been explored. A simple (dilute-and-shoot) interference-free method has been developed to quantify As concentrations at trace and ultra-trace levels in matrices with a high Cl content. As+ reacts with CH3F (through CH3F addition, followed by HF elimination) with high efficiency forming AsCH2 + as the primary reaction product, which can be monitored at a mass-to-charge ratio of 89, free from the Cl-based interferents (e.g., 40Ar35Cl+ and 40Ca35Cl+) that hamper the monitoring of 75As+. Matrix effects are overcome by the use of Te as an internal standard and the addition of 3% v/v ethanol to all samples and calibration standard solutions. The method presented was validated by analysing a set of reference materials (blood, serum and urine) and by assessing As recovery from a set of real blood samples. With this method, the limit of detection was calculated to be 0.8 ng L-1 As, favourably comparable to the vast majority of values reported in the literature, even with those obtained using more sophisticated sector-field instrumentation.
Idioma: Inglés
DOI: 10.1039/c5ja00298b
Año: 2016
Publicado en: Journal of Analytical Atomic Spectrometry 31, 1 (2016), 245-251
ISSN: 0267-9477

Factor impacto JCR: 3.379 (2016)
Categ. JCR: SPECTROSCOPY rank: 6 / 41 = 0.146 (2016) - Q1 - T1
Categ. JCR: CHEMISTRY, ANALYTICAL rank: 17 / 76 = 0.224 (2016) - Q1 - T1

Factor impacto SCIMAGO: 1.004 - Spectroscopy (Q1) - Analytical Chemistry (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MINECO/CTQ2012-33494
Tipo y forma: Article (PostPrint)
Área (Departamento): Área Química Analítica (Dpto. Química Analítica)

Rights Reserved All rights reserved by journal editor

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