61323 20210121114524.0 sideral 89411 ART-2015-89411 eng Fiuza-Luces, C. Understanding graft-versus-host disease. Preliminary findings regarding the effects of exercise in affected patients 2015 Access copy available to the general public Unrestricted Advances in this century regarding allogeneic hematopoietic stem cell transplantation (allo-HSCT) have led to an expanding population of long-term survivors, many of whom suffer severe side effects, particularly those related to graft-versushost disease (GVHD), a potentially multi-systemic disorder caused by immunoeffector donor lymphocytes that destroy host tissues. The GVHD, especially in its chronic form (cGVHD), generates considerable morbidity and compromises the physical capacity of patients. We have reviewed the main pathophysiological aspects of the disease as well as the data available on the effects of exercise in GVHD, based on animal and human patient research. Although exercise training as an adjunct therapy to improve health outcomes after allo-HSCT shows promise (particularly, this lifestyle intervention can improve physical fitness and possibly immune function while attenuating fatigue), there is a need for more randomized control trials that focus specifically on GVHD. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.294 2015 SPORT SCIENCES 5 / 82 = 0.061 2015 Q1 T1 IMMUNOLOGY 39 / 151 = 0.258 2015 Q2 T1 1.799 2015 Sports Science 2015 Q1 Immunology 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0001-8374-9081 Garatachea, N. Universidad de Zaragoza Simpson, RJ. Berger, NA. Ramírez, M. Lucia, A. 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 21 (2015), 80-112 Exerc. immunol. rev. EXERCISE IMMUNOLOGY REVIEW 1077-5552 3201176 http://zaguan.unizar.es/record/61323/files/texto_completo.pdf Versión publicada 9948 http://zaguan.unizar.es/record/61323/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:61323 articulos driver 2021-01-21-11:05:03 ARTICLE