61441 20211117102002.0 doi 10.1039/C6RA10058A sideral 96457 ART-2016-96457 eng Encabo-Berzosa, M. Mar Universidad de Zaragoza (orcid)0000-0003-4891-105X Selective delivery of photothermal nanoparticles to tumors using mesenchymal stem cells as Trojan horses 2016 Access copy available to the general public Unrestricted The main challenge of cancer treatment is to avoid or minimize systemic side effects in off-target tissues. Mesenchymal stem cells (MSCs) can be used as therapeutical carriers because of their ability to migrate and incorporate into inflammation areas including tumors. Here, this homing ability is exploited by carrying therapeutic nanoparticles (Hollow Gold Nanoparticles (HGNs)) following a “Trojan-horse” strategy. Amongst the different nanoparticles to be employed, HGNs have the capacity to resonate in the near infrared region when irradiated by an appropriated laser (808 nm). By transforming this absorbed energy into heat, they are capable to produce locally induced hyperthermia. At this wavelength healthy tissues have a minimal light absorption being the effect restricted to the tissues containing HGNs. By placing HGNs inside MSCs, the recognition, excretion and immune response are minimized. We demonstrate that MSCs internalize HGNs and reach the tumors still containing HGNs. After laser treatment this loaded cells are able to eradicate tumoral cells in vitro and in vivo without significant toxicity. Also Ki67 expression, which is usually correlated with proliferation, is reduced after treatment. This approach enhances the effectiveness of the treatment when compared to just the enhanced permeation and retention effect (EPR) of the HGNs by themselves. info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 3.108 2016 CHEMISTRY, MULTIDISCIPLINARY 59 / 166 = 0.355 2016 Q2 T2 0.889 2016 Chemistry (miscellaneous) 2016 Q1 Chemical Engineering (miscellaneous) 2016 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Gimeno, Marina Luján, Lluis Universidad de Zaragoza (orcid)0000-0002-2053-9842 Sancho-Albero, María Universidad de Zaragoza (orcid)0000-0001-8762-5457 Gómez, Leire Sebastián, Víctor Universidad de Zaragoza (orcid)0000-0002-6873-5244 Quintanilla, Miguel Arruebo, Manuel Universidad de Zaragoza (orcid)0000-0003-3165-0156 Santamaría, Jesús Universidad de Zaragoza (orcid)0000-0002-8701-9745 Martín-Duque, Pilar (orcid)0000-0003-4160-9720 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 6, 63 (2016), 58723-58732 RSC ADVANCES RSC Advances 2046-2069 2035117 http://zaguan.unizar.es/record/61441/files/texto_completo.pdf Postprint 109088 http://zaguan.unizar.es/record/61441/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:61441 articulos driver 2021-11-15-14:34:07 ARTICLE