000061450 001__ 61450
000061450 005__ 20170612112601.0
000061450 0247_ $$2doi$$a10.1371/journal.pone.0073320
000061450 0248_ $$2sideral$$a83218
000061450 037__ $$aART-2013-83218
000061450 041__ $$aeng
000061450 100__ $$aLorente, L.
000061450 245__ $$aSevere Septic Patients with Mitochondrial DNA Haplogroup JT Show Higher Survival Rates: A Prospective, Multicenter, Observational Study
000061450 260__ $$c2013
000061450 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061450 5203_ $$aObjective
In a previous cohort study (n=96), we found an association between mitochondrial (mt) DNA haplogroup JT and increased survival of severe septic patients, after controlling for age and serum lactic acid levels. The aim of this research was to increase the predictive accuracy and to control for more confounder variables in a larger cohort (n=196) of severe septic patients, to confirm whether mtDNA haplogroup JT influences short and medium-term survival in these patients.
Methods
We conducted a prospective, multicenter, observational study in six Spanish Intensive Care Units. We determined 30-day and 6-month survival and mtDNA haplogroup in this second cohort of 196 patients and in the global cohort (first and second cohorts combined) with 292 severe septic patients. Multiple logistic regression and Cox regression analyses were used to test for the association of mtDNA haplogroups JT with survival at 30-days and 6-months, controlling for age, sex, serum interleukin-6 levels and SOFA score.
Results
Logistic and Cox regression analyses showed no differences in 30-day and 6-month survival between patients with mtDNA haplogroup JT and other haplogroups in the first cohort (n=96). In the second cohort (n=196), these analyses showed a trend to higher 30-day and 6-month survival in those with haplogroup JT. In the global cohort (n=292), logistic and Cox regression analyses showed higher 30-day and 6-month survival for haplogroup JT. There were no significant differences between J and T sub-haplogroups in 30-day and 6-month survival.
Conclusions
The global cohort study (first and second cohorts combined), the largest to date reporting on mtDNA haplogroups in septic patients, confirmed that haplogroup JT patients showed increased 30-day and 6-month survival. This finding may be due to single nucleotide polymorphism defining the whole haplogroup JT and not separately for J or T sub-haplogroups.
000061450 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B33$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI10-00662$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI10-01301$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI10-01572$$9info:eu-repo/grantAgreement/ES/ISCIII/I3SNS-INT-11-063$$9info:eu-repo/grantAgreement/ES/ISCIII/I3SNS-INT-12-087
000061450 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000061450 590__ $$a3.534$$b2013
000061450 591__ $$aMULTIDISCIPLINARY SCIENCES$$b8 / 55 = 0.145$$c2013$$dQ1$$eT1
000061450 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000061450 700__ $$aIceta, R.
000061450 700__ $$aMartín, M.M.
000061450 700__ $$0(orcid)0000-0002-3217-1424$$aLópez-Gallardo, E.$$uUniversidad de Zaragoza
000061450 700__ $$aSolé-Violán, J.
000061450 700__ $$aBlanquer, J.
000061450 700__ $$aLabarta, L.
000061450 700__ $$aDíaz, C.
000061450 700__ $$aBorreguero-León, J.M.
000061450 700__ $$0(orcid)0000-0003-1770-6299$$aJiménez, A.$$uUniversidad de Zaragoza
000061450 700__ $$aMontoya, J.
000061450 700__ $$0(orcid)0000-0002-0269-7337$$aRuiz-Pesini, E.$$uUniversidad de Zaragoza
000061450 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDepartamento de Bioquímica y Biología Molecular y Celular$$cBioquímica y Biología Molecular
000061450 773__ $$g8, 9 (2013), e73320 [7 pp]$$pPLoS One$$tPLoS One$$x1932-6203
000061450 8564_ $$s423052$$uhttps://zaguan.unizar.es/record/61450/files/texto_completo.pdf$$yVersión publicada
000061450 8564_ $$s127053$$uhttps://zaguan.unizar.es/record/61450/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000061450 909CO $$ooai:zaguan.unizar.es:61450$$particulos$$pdriver
000061450 951__ $$a2017-06-12-09:14:09
000061450 980__ $$aARTICLE