61502 20230210140617.0 doi 10.1039/c6ra23620k sideral 98829 ART-2016-98829 eng Español, L. Dual encapsulation of hydrophobic and hydrophilic drugs in PLGA nanoparticles by a single-step method: Drug delivery and cytotoxicity assays 2016 Access copy available to the general public Unrestricted Dual drug encapsulation in biodegradable nanoparticles is always challenging and often requires strenuous optimization of the synthesis-encapsulation processes. This becomes even more difficult when the simultaneous encapsulation of molecules of different polarity is sought. Here we present a modified emulsification-evaporation process to produce polymeric nanoparticles (NPs) made of the biocompatible and biodegradable polymer poly(lactic-co-glycolic acid) (PLGA) and co-encapsulating simultaneously two different drugs, the hydrophobic dexamethasone (DX) and the hydrophilic diclofenac sodium (DS). Three independent processing parameters were systematically modified to promote the incorporation of the different-polarity drugs into PLGA and to control the particle size under 150 nm. The careful selection of the appropriate solvents (ethyl acetate and methanol) was a key requirement for the successful encapsulation of DX and DS. DS and DX release kinetics as well as cytotoxicity assays underlined the therapeutic potential of the dual encapsulation strategy. © 2016 The Royal Society of Chemistry. info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.108 2016 CHEMISTRY, MULTIDISCIPLINARY 59 / 166 = 0.355 2016 Q2 T2 0.889 2016 Chemistry (miscellaneous) 2016 Q1 Chemical Engineering (miscellaneous) 2016 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Larrea, A. Universidad de Zaragoza (orcid)0000-0002-6277-7996 Andreu, V. Mendoza, G. (orcid)0000-0003-2293-363X Arruebo, M. Universidad de Zaragoza (orcid)0000-0003-3165-0156 Sebastian, V. Universidad de Zaragoza (orcid)0000-0002-6873-5244 Aurora-Prado, M.S. Kedor-Hackmann, E.R.M. Santoro, M.I.R.M. Santamaria, J. Universidad de Zaragoza (orcid)0000-0002-8701-9745 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 6, 112 (2016), 111060-111069 RSC ADVANCES RSC Advances 2046-2069 1580602 http://zaguan.unizar.es/record/61502/files/texto_completo.pdf Versión publicada 120405 http://zaguan.unizar.es/record/61502/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:61502 articulos driver 2023-02-10-13:59:39 ARTICLE