61545 20210902121558.0 doi 10.1039/c6ra01714b sideral 94008 ART-2016-94008 eng Oriol Langa, Luis Teodoro Universidad de Zaragoza (orcid)0000-0002-0922-5615 Polymeric micelles from block copolymers containing 2,6-diacylaminopyridine units for encapsulation of hydrophobic drugs 2016 Access copy available to the general public Unrestricted The paper describes the synthesis and characterization of novel amphiphilic block copolymers composed of a hydrophilic (polyethylene glycol) block and a hydrophobic polymetacrylate block with pendant 2,6-acylaminopyridine units. As demonstrated by TEM, these polymers are capable of forming stable spherical micelles in water with diameters of 18-25 nm, depending on the average molar mass, determined by dynamic light scattering. The polymeric micelles are sensitive to pH and can encapsulate hydrophobic molecules such as Nile Red. The cytotoxicity of the block copolymers has been tested in HeLa and Lunet cell lines and proved to be adequate. The polymeric micelles have been used to load camptothecin (CPT), an effective antiviral against hepatitis C virus (HCV), by simple physical diffusion. The antiviral activity against HVC of these CPT-loaded polymeric micelles has been tested on Huh 5-2 Lunet cells, demonstrating the potential of these polymers as nanocarriers for drug delivery applications. info:eu-repo/grantAgreement/ES/MINECO/BFU2013-47064-P info:eu-repo/grantAgreement/ES/MINECO/MAT2014-55205-P info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 3.108 2016 CHEMISTRY, MULTIDISCIPLINARY 59 / 166 = 0.355 2016 Q2 T2 0.889 2016 Chemistry (miscellaneous) 2016 Q1 Chemical Engineering (miscellaneous) 2016 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Concellón, A. Universidad de Zaragoza (orcid)0000-0002-8932-9085 Clavería-Gimeno, R. Velázquez-Campoy, A. Universidad de Zaragoza (orcid)0000-0001-5702-4538 Abian, O. Universidad de Zaragoza (orcid)0000-0001-5664-1729 Piñol, M. Universidad de Zaragoza (orcid)0000-0001-5556-2172 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 6, 29 (2016), 24066 - 24075 RSC ADVANCES RSC Advances 2046-2069 1190183 http://zaguan.unizar.es/record/61545/files/texto_completo.pdf Versión publicada 120070 http://zaguan.unizar.es/record/61545/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:61545 articulos driver 2021-09-02-08:33:31 ARTICLE