000061620 001__ 61620 000061620 005__ 20240118091946.0 000061620 0247_ $$2doi$$a10.3390/nu9050472 000061620 0248_ $$2sideral$$a99009 000061620 037__ $$aART-2017-99009 000061620 041__ $$aeng 000061620 100__ $$0(orcid)0000-0002-4665-9674$$aHerrera-Marcos, L.V.$$uUniversidad de Zaragoza 000061620 245__ $$aTranscriptomics and the mediterranean diet: A systematic review 000061620 260__ $$c2017 000061620 5060_ $$aAccess copy available to the general public$$fUnrestricted 000061620 5203_ $$aThe Mediterranean diet has been proven to be highly effective in the prevention of cardiovascular diseases and cancer and in decreasing overall mortality. Nowadays, transcriptomics is gaining particular relevance due to the existence of non-coding RNAs capable of regulating many biological processes. The present work describes a systematic review of current evidence supporting the influence of the Mediterranean diet on transcriptomes of different tissues in various experimental models. While information on regulatory RNA is very limited, they seem to contribute to the effect. Special attention has been given to the oily matrix of virgin olive oil. In this regard, monounsaturated fatty acid-rich diets prevented the expression of inflammatory genes in different tissues, an action also observed after the administration of olive oil phenolic compounds. Among these, tyrosol, hydroxytyrosol, and secoiridoids have been found to be particularly effective in cell cycle expression. Less explored terpenes, such as oleanolic acid, are important modulators of circadian clock genes. The wide range of studied tissues and organisms indicate that response to these compounds is universal and poses an important level of complexity considering the different genes expressed in each tissue and the number of different tissues in an organism. 000061620 536__ $$9info:eu-repo/grantAgreement/ES/CICYT-FEDER/2013-41651-R$$9info:eu-repo/grantAgreement/ES/DGA/B69 000061620 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000061620 590__ $$a4.196$$b2017 000061620 591__ $$aNUTRITION & DIETETICS$$b18 / 79 = 0.228$$c2017$$dQ1$$eT1 000061620 592__ $$a1.557$$b2017 000061620 593__ $$aNutrition and Dietetics$$c2017$$dQ1 000061620 593__ $$aFood Science$$c2017$$dQ1 000061620 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion 000061620 700__ $$0(orcid)0000-0001-9578-6525$$aLou-Bonafonte, J.M.$$uUniversidad de Zaragoza 000061620 700__ $$0(orcid)0000-0003-1197-4276$$aArnal, C.$$uUniversidad de Zaragoza 000061620 700__ $$0(orcid)0000-0002-0108-1004$$aNavarro, M.A.$$uUniversidad de Zaragoza 000061620 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, J.$$uUniversidad de Zaragoza 000061620 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología 000061620 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal 000061620 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000061620 773__ $$g9, 5 (2017), 472 [17 pp]$$pNutrients$$tNutrients$$x2072-6643 000061620 8564_ $$s1263496$$uhttps://zaguan.unizar.es/record/61620/files/texto_completo.pdf$$yVersión publicada 000061620 8564_ $$s105066$$uhttps://zaguan.unizar.es/record/61620/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000061620 909CO $$ooai:zaguan.unizar.es:61620$$particulos$$pdriver 000061620 951__ $$a2024-01-18-09:10:20 000061620 980__ $$aARTICLE