61661 20191105115759.0 doi 10.1016/j.redox.2017.05.026 sideral 99643 ART-2017-99643 eng (orcid)0000-0002-4379-1100 Llobet, L. Pharmacologic concentrations of linezolid modify oxidative phosphorylation function and adipocyte secretome 2017 Access copy available to the general public Unrestricted The oxidative phosphorylation system is important for adipocyte differentiation. Therefore, xenobiotics inhibitors of the oxidative phosphorylation system could affect adipocyte differentiation and adipokine secretion. As adipokines impact the overall health status, these xenobiotics may have wide effects on human health. Some of these xenobiotics are widely used therapeutic drugs, such as ribosomal antibiotics. Because of its similarity to the bacterial one, mitochondrial translation system is an off-target for these compounds. To study the influence of the ribosomal antibiotic linezolid on adipokine production, we analyzed its effects on adipocyte secretome. Linezolid, at therapeutic concentrations, modifies the levels of apolipoprotein E and several adipokines and proteins related with the extracellular matrix. This antibiotic also alters the global methylation status of human adipose tissue-derived stem cells and, therefore, its effects are not limited to the exposure period. Besides their consequences on other tissues, xenobiotics acting on the adipocyte oxidative phosphorylation system alter apolipoprotein E and adipokine production, secondarily contributing to their systemic effects. info:eu-repo/grantAgreement/ES/DGA/B33 info:eu-repo/grantAgreement/ES/FIS/PI14-00005 info:eu-repo/grantAgreement/ES/FIS/PI14-00070 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 7.126 2017 BIOCHEMISTRY & MOLECULAR BIOLOGY 31 / 292 = 0.106 2017 Q1 T1 2.203 2017 Biochemistry 2017 Q1 Organic Chemistry 2017 Q1 Clinical Biochemistry 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0002-8585-6371 Bayona-Bafaluy, M.P. Universidad de Zaragoza Pacheu-Grau, D. Torres-Pérez, E. Arbones-Mainar, J.M. (orcid)0000-0002-0108-1004 Navarro, M.Á. Universidad de Zaragoza Gómez-Díaz, C. (orcid)0000-0003-1770-6299 Montoya, J. Universidad de Zaragoza (orcid)0000-0002-3217-1424 López-Gallardo, E. Universidad de Zaragoza (orcid)0000-0002-0269-7337 Ruiz-Pesini, E. Universidad de Zaragoza 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 13 (2017), 244-254 Redox biol. Redox Biology 2213-2317 1033065 http://zaguan.unizar.es/record/61661/files/texto_completo.pdf Versión publicada 98013 http://zaguan.unizar.es/record/61661/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:61661 articulos driver 2019-11-05-11:49:54 ARTICLE