000061705 001__ 61705
000061705 005__ 20190219123621.0
000061705 037__ $$aTESIS-2017-064
000061705 041__ $$aeng
000061705 080__ $$a621
000061705 1001_ $$aMonge Prieto, Rosa María
000061705 24500 $$aDevelopment and application of microtechnologies in the design and fabrication of cell culture biomimetic systems
000061705 260__ $$aZaragoza$$bUniversidad de Zaragoza, Prensas de la Universidad$$c2017
000061705 300__ $$a150
000061705 4900_ $$aTesis de la Universidad de Zaragoza$$v2017-64$$x2254-7606
000061705 500__ $$aPresentado: 16 06 2017
000061705 502__ $$aTesis-Univ. Zaragoza, Ingeniería Mecánica, 2017$$bZaragoza, Universidad de Zaragoza$$c2017
000061705 506__ $$aby-nc-nd$$bCreative Commons$$c3.0$$uhttps://creativecommons.org/licenses/by-nc-nd/3.0/
000061705 520__ $$a“Lab-On-a-chip” systems have proved to be a promising tool in the field of biology. Currently, cell culture is performed massively on Petri dishes, which have traditionally been used in cell culture laboratories and tissue engineering. However, having proved to be a widely used tool until now, the scientific community has largely described the lack of correlation between the results obtained in the laboratory and the clinical results. This lack of connection between what has been studied in the laboratories and what has been observed in the clinic has led to the search for more advanced alternative tools that allow results to be obtained closer to reality. Thus, the use of microtechnologies in the field of biomedical engineering, presents itself as the perfect tool as an alternative to obsolete traditional media. Thanks to the low volumes of liquid it presents for its use, it also makes it an essential technology for the testing of drugs, new compounds and materials. By being able to more accurately reproduce the biomimetic environment of cell cultures and tissues, they make this technique fundamental as an intermediate step between basic in vitro laboratory tests and preclinical animal tests, resulting from this way in the best alternative for the reduction of both the use of animal models, as in times and costs. For a biomimetic system to be as such, it also needs another series of complementary devices for its better functioning. Micro-valves, micro pumps, flow sensors, O2 sensors, pH, CO2 are fundamental for the correct functioning and<br />sophistication of biomimetic systems. This complexity, on the other hand, is often not perceived by the user since the miniaturization of all these components makes “Lab-On-a-Chip” systems smaller every day, despite numerous control components that can be incorporated.<br />This thesis presents some examples of different microfluidic devices designed and manufactured through the use of microtechnologies, with all applications, focused on their use in biomimetic systems.<br />
000061705 520__ $$a<br />
000061705 6531_ $$abiomecánica
000061705 6531_ $$amicroelectrónica
000061705 700__ $$aFernández Ledesma, Luis José$$edir.
000061705 700__ $$aOchoa Garrido, Ignacio$$edir.
000061705 700__ $$aDoblaré Castellano, Manuel$$edir.
000061705 7102_ $$aUniversidad de Zaragoza$$bIngeniería Mecánica
000061705 8560_ $$fchperez@unizar.es
000061705 8564_ $$s4487466$$uhttps://zaguan.unizar.es/record/61705/files/TESIS-2017-064.pdf$$zTexto completo (eng)
000061705 909CO $$ooai:zaguan.unizar.es:61705$$pdriver
000061705 909co $$ptesis
000061705 9102_ $$aIngeniería mecánica$$bIngeniería Mecánica
000061705 980__ $$aTESIS