61718 20190709135448.0 doi 10.1371/journal.pcbi.1005277 sideral 99226 ART-2017-99226 eng Bidone, T.C. Morphological Transformation and Force Generation of Active Cytoskeletal Networks 2017 Access copy available to the general public Unrestricted Cells assemble numerous types of actomyosin bundles that generate contractile forces for biological processes, such as cytokinesis and cell migration. One example of contractile bundles is a transverse arc that forms via actomyosin-driven condensation of actin filaments in the lamellipodia of migrating cells and exerts significant forces on the surrounding environments. Structural reorganization of a network into a bundle facilitated by actomyosin contractility is a physiologically relevant and biophysically interesting process. Nevertheless, it remains elusive how actin filaments are reoriented, buckled, and bundled as well as undergo tension buildup during the structural reorganization. In this study, using an agent-based computational model, we demonstrated how the interplay between the density of myosin motors and cross-linking proteins and the rigidity, initial orientation, and turnover of actin filaments regulates the morphological transformation of a cross-linked actomyosin network into a bundle and the buildup of tension occurring during the transformation. info:eu-repo/grantAgreement/EUR/FP7/ERC2012-StG-306751 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.955 2017 MATHEMATICAL & COMPUTATIONAL BIOLOGY 5 / 59 = 0.085 2017 Q1 T1 BIOCHEMICAL RESEARCH METHODS 13 / 79 = 0.165 2017 Q1 T1 3.097 2017 Cellular and Molecular Neuroscience 2017 Q1 Computational Theory and Mathematics 2017 Q1 Ecology 2017 Q1 Molecular Biology 2017 Q1 Genetics 2017 Q1 Modeling and Simulation 2017 Q1 Ecology, Evolution, Behavior and Systematics 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Jung, W. Maruri, D. (orcid)0000-0002-3784-1140 Borau, C. Universidad de Zaragoza Kamm, R.D. Kim, T. 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 13, 1 (2017), e1005277[22 pp] PLoS Comput. Biol. PLoS computational biology 1553-7358 5639276 http://zaguan.unizar.es/record/61718/files/texto_completo.pdf Versión publicada 104320 http://zaguan.unizar.es/record/61718/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:61718 articulos driver 2019-07-09-11:39:30 ARTICLE