000061865 001__ 61865
000061865 005__ 20200221144220.0
000061865 0247_ $$2doi$$a10.1039/c6nr04678a
000061865 0248_ $$2sideral$$a96342
000061865 037__ $$aART-2016-96342
000061865 041__ $$aeng
000061865 100__ $$aMartín, M.
000061865 245__ $$aMagnetic study on biodistribution and biodegradation of oral magnetic nanostructures in the rat gastrointestinal tract
000061865 260__ $$c2016
000061865 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061865 5203_ $$aWe have undertaken a magnetic study on the oral biodistribution and biodegradation of nude maghemite nanoparticles of 10 nm average size (MNP) and probiotic bacteria, Lactobacillus fermentum, containing thousands of these same nanoparticles (MNP-bacteria). Using AC magnetic susceptibility measurements of the stomach, small intestine, cecum and large intestine obtained after rat sacrifice, and iron content determination by ICP-OES, we have monitored the biodistribution and biodegradation of the maghemite nanoparticles along the gastrointestinal tract, after oral administration of both MNP and MNP-bacteria. The results revealed that the amount of magnetic nanoparticles accumulated in intestines is sensibly higher when MNP-bacteria were administered, in comparison with MNP. This confirms our initial hypothesis that the use of probiotic bacteria is a suitable strategy to assist the magnetic nanoparticles to overcome the stomach medium, and to achieve their accumulation in intestines. This finding opens doors to different applications. Since iron absorption in humans takes place precisely in the intestines, the use of MNP-bacteria as an iron supplement is a definite possibility. We have actually illustrated how the administration of MNP-bacteria to iron-deficient rats corrects the iron levels after two weeks of treatment.
000061865 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/RYC-2014-15512$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2015-64538-R
000061865 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000061865 590__ $$a7.367$$b2016
000061865 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b23 / 275 = 0.084$$c2016$$dQ1$$eT1
000061865 591__ $$aNANOSCIENCE & NANOTECHNOLOGY$$b13 / 87 = 0.149$$c2016$$dQ1$$eT1
000061865 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b21 / 166 = 0.127$$c2016$$dQ1$$eT1
000061865 591__ $$aPHYSICS, APPLIED$$b13 / 147 = 0.088$$c2016$$dQ1$$eT1
000061865 592__ $$a2.789$$b2016
000061865 593__ $$aNanoscience and Nanotechnology$$c2016$$dQ1
000061865 593__ $$aMaterials Science (miscellaneous)$$c2016$$dQ1
000061865 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000061865 700__ $$aRodríguez-Nogales, A.
000061865 700__ $$aGarcés, V.
000061865 700__ $$aGálvez, N.
000061865 700__ $$0(orcid)0000-0003-2366-3598$$aGutiérrez, L.$$uUniversidad de Zaragoza
000061865 700__ $$aGálvez, J.
000061865 700__ $$aRondón, D.
000061865 700__ $$aOlivares, M.
000061865 700__ $$aDominguez-Vera, J.
000061865 7102_ $$12009$$2750$$aUniversidad de Zaragoza$$bDpto. Química Analítica$$cÁrea Química Analítica
000061865 773__ $$g8, 32 (2016), 15041-15047$$pNanoscale$$tNANOSCALE$$x2040-3364
000061865 8564_ $$s1085927$$uhttps://zaguan.unizar.es/record/61865/files/texto_completo.pdf$$yPostprint
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000061865 909CO $$ooai:zaguan.unizar.es:61865$$particulos$$pdriver
000061865 951__ $$a2020-02-21-13:14:35
000061865 980__ $$aARTICLE