000061951 001__ 61951
000061951 005__ 20190709135515.0
000061951 0247_ $$2doi$$a10.1186/s13613-017-0303-4
000061951 0248_ $$2sideral$$a100721
000061951 037__ $$aART-2017-100721
000061951 041__ $$aeng
000061951 100__ $$aTuron, M.
000061951 245__ $$aFeasibility and safety of virtual-reality-based early neurocognitive stimulation in critically ill patients
000061951 260__ $$c2017
000061951 5060_ $$aAccess copy available to the general public$$fUnrestricted
000061951 5203_ $$aBackground: Growing evidence suggests that critical illness often results in significant long-term neurocognitive impairments in one-third of survivors. Although these neurocognitive impairments are long-lasting and devastating for survivors, rehabilitation rarely occurs during or after critical illness. Our aim is to describe an early neurocognitive stimulation intervention based on virtual reality for patients who are critically ill and to present the results of a proof-of-concept study testing the feasibility, safety, and suitability of this intervention. Methods: Twenty critically ill adult patients undergoing or having undergone mechanical ventilation for =24 h received daily 20-min neurocognitive stimulation sessions when awake and alert during their ICU stay. The difficulty of the exercises included in the sessions progressively increased over successive sessions. Physiological data were recorded before, during, and after each session. Safety was assessed through heart rate, peripheral oxygen saturation, and respiratory rate. Heart rate variability analysis, an indirect measure of autonomic activity sensitive to cognitive demands, was used to assess the efficacy of the exercises in stimulating attention and working memory. Results: Patients successfully completed the sessions on most days. No sessions were stopped early for safety concerns, and no adverse events occurred. Heart rate variability analysis showed that the exercises stimulated attention and working memory. Critically ill patients considered the sessions enjoyable and relaxing without being overly fatiguing. Conclusions: The results in this proof-of-concept study suggest that a virtual-reality-based neurocognitive intervention is feasible, safe, and tolerable, stimulating cognitive functions and satisfying critically ill patients. Future studies will evaluate the impact of interventions on neurocognitive outcomes. Trial registration Clinical trials.gov identifier: NCT02078206.
000061951 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/PI13-02204
000061951 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000061951 590__ $$a3.771$$b2017
000061951 591__ $$aCRITICAL CARE MEDICINE$$b9 / 33 = 0.273$$c2017$$dQ2$$eT1
000061951 592__ $$a1.819$$b2017
000061951 593__ $$aCritical Care and Intensive Care Medicine$$c2017$$dQ1
000061951 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000061951 700__ $$aFernandez-Gonzalo, S.
000061951 700__ $$aJodar, M.
000061951 700__ $$aGomà, G.
000061951 700__ $$aMontanya, J.
000061951 700__ $$0(orcid)0000-0002-1462-4880$$aHernando, D.
000061951 700__ $$0(orcid)0000-0003-1272-0550$$aBailón, R.$$uUniversidad de Zaragoza
000061951 700__ $$ade Haro, C.
000061951 700__ $$aGomez-Simon, V.
000061951 700__ $$aLopez-Aguilar, J.
000061951 700__ $$aMagrans, R.
000061951 700__ $$aMartinez-Perez, M.
000061951 700__ $$aOliva, J.C.
000061951 700__ $$aBlanch, L.
000061951 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000061951 773__ $$g7, 81 (2017), [11 pp]$$pAnn. intensive care$$tAnnals of intensive care$$x2110-5820
000061951 8564_ $$s1219518$$uhttps://zaguan.unizar.es/record/61951/files/texto_completo.pdf$$yVersión publicada
000061951 8564_ $$s93701$$uhttps://zaguan.unizar.es/record/61951/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000061951 909CO $$ooai:zaguan.unizar.es:61951$$particulos$$pdriver
000061951 951__ $$a2019-07-09-11:54:42
000061951 980__ $$aARTICLE