61971 20210526094556.0 doi 10.1038/ncomms16085 sideral 100829 ART-2017-100829 eng (orcid)0000-0001-7897-9173 Aguilo, Nacho Universidad de Zaragoza Reactogenicity to major tuberculosis antigens absent in BCG is linked to improved protection against Mycobacterium tuberculosis 2017 Access copy available to the general public Unrestricted MTBVAC is a live-attenuated Mycobacterium tuberculosis vaccine, currently under clinical development, that contains the major antigens ESAT6 and CFP10. These antigens are absent from the current tuberculosis vaccine, BCG. Here we compare the protection induced by BCG and MTBVAC in several mouse strains that naturally express different MHC haplotypes differentially recognizing ESAT6 and CFP10. MTBVAC induces improved protection in C3H mice, the only of the three tested strains reactive to both ESAT6 and CFP10. Deletion of both antigens in MTBVAC reduces its efficacy to BCG levels, supporting a link between greater efficacy and CFP10- and ESAT6-specific reactogenicity. In addition, MTBVAC (but not BCG) triggers a specific response in human vaccinees against ESAT6 and CFP10. Our results warrant further exploration of this response as potential biomarker of protection in MTBVAC clinical trials. info:eu-repo/grantAgreement/ES/MINECO/BIO2014-5258P This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 643381-TBVAC2020 info:eu-repo/grantAgreement/EC/H2020/643381/EU/TBVAC2020; Advancing novel and promising TB vaccine candidates from discovery to preclinical and early clinical development/TBVAC2020 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 12.353 2017 MULTIDISCIPLINARY SCIENCES 3 / 64 = 0.047 2017 Q1 T1 6.582 2017 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2017 Q1 Physics and Astronomy (miscellaneous) 2017 Q1 Chemistry (miscellaneous) 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0001-8841-6593 Gonzalo-Asensio, Jesús Universidad de Zaragoza (orcid)0000-0002-5748-6078 Alvarez-Arguedas, Samuel Universidad de Zaragoza (orcid)0000-0001-8644-120X Marinova, Dessislava Universidad de Zaragoza (orcid)0000-0002-9713-2127 Gomez, Ana Belen Universidad de Zaragoza (orcid)0000-0001-7866-2803 Uranga, Santiago Universidad de Zaragoza Spallek, Ralf Singh, Mahavir Audran, Regine Spertini, François (orcid)0000-0003-2993-5478 Martin, Carlos Universidad de Zaragoza 1008 630 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Microbiología 1008 X Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Proy. investigación HQA 8 (2017), 16085 [11 pp.] NATURE COMMUNICATIONS Nature Communications 2041-1723 1038065 http://zaguan.unizar.es/record/61971/files/texto_completo.pdf Versión publicada 67492 http://zaguan.unizar.es/record/61971/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:61971 articulos driver 2021-05-26-09:31:16 ARTICLE