62089 20190709135518.0 doi 10.20960/nh.559 sideral 100849 ART-2017-100849 eng (orcid)0000-0002-2219-3646 Iglesia, I. Associations between insulin resistance and three B-vitamins in european adolescents: The HELENA study 2017 Access copy available to the general public Unrestricted Objective: To assess whether adolescents with high body mass index (BMI), or fat mass index (FMI), in combination with insulin resistance (assessed with the Homeostatic Model Assessment [HOMA] index), had also lower blood vitamin B6, folate and vitamin B12 concentrations. Methods and materials: Six hundred and fifteen adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study, with data on B-vitamins (both intakes and status), and BMI, FMI, HOMA, were selected. Intakes were assessed by two non-consecutive 24-h recalls. B-vitamins biomarkers were measured by chromatography and immunoassay. Analysis of covariance was applied to elucidate the differences in B-vitamins between combinations of groups defined according to the median of the z-scores of markers of body composition and insulin sensitivity. Results: When considering energy intakes and education of the mother in the model, in females, vitamin B6 intakes were higher in the high BMI/ high HOMA group than in the high BMI-low HOMA group. Similarly, vitamin B6 intakes were higher in the high FMI/high HOMA group than in the low FMI/low HOMA group. Plasma vitamin B12 was significantly lower in males in the high FMI/high HOMA group than in the low FMI/low HOMA group, keeping also significant their trends throughout the groups, a fact that can be observed also for females (p < 0.05). Conclusion: Adolescents with combined higher adiposity and higher HOMA insulin sensitivity showed lower vitamin B12 plasma concentrations. These differences do not seem to be explained by dietary vitamin B12 intake. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 0.411 2017 Nutrition and Dietetics 2017 Q3 Medicine (miscellaneous) 2017 Q3 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion González-Gross, M. Huybrechts, I. De-Miguel-Etayo, P. Molnar, D. Manios, Y. Widhalm, K. Gottrand, F. Kafatos, A. Marcos, A. Puerta, A.O. Leclerc, C. De Henauw, S. Stehle, P. Kersting, M. (orcid)0000-0002-3726-1066 Mouratidou, T. (orcid)0000-0003-0454-653X Moreno, L.A. Universidad de Zaragoza 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 34, 3 (2017), 568-577 Nutr. hosp. NUTRICION HOSPITALARIA 0212-1611 http://revista.nutricionhospitalaria.net/index.php/nh/article/view/559/563 Texto completo de la revista 816424 http://zaguan.unizar.es/record/62089/files/texto_completo.pdf Versión publicada 15117 http://zaguan.unizar.es/record/62089/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:62089 articulos driver 2019-07-09-11:56:12 ARTICLE