000062982 001__ 62982
000062982 005__ 20190709135504.0
000062982 0247_ $$2doi$$a10.1109/TBME.2016.2614899
000062982 0248_ $$2sideral$$a101483
000062982 037__ $$aART-2017-101483
000062982 041__ $$aeng
000062982 100__ $$0(orcid)0000-0003-4130-5866$$aRamírez, Julia$$uUniversidad de Zaragoza
000062982 245__ $$aVariability of ventricular repolarization dispersion quantified by time-warping the morphology of the T-Waves
000062982 260__ $$c2017
000062982 5060_ $$aAccess copy available to the general public$$fUnrestricted
000062982 5203_ $$aObjective: We propose two electrocardiogram (ECG)-derived markers of T-wave morphological variability in the temporal, d¿, and amplitude, da, domains. Two additional markers, d¿NL and daNL, restricted to measure the nonlinear information present within d¿ and da are also proposed. Methods: We evaluated the accuracy of the proposed markers in capturing T-wave time and amplitude variations in 3 situations: 1) In a simulated set up with presence of additive Laplacian noise, 2) when modifying the spatio-temporal distribution of electrical repolarization with an electro-physiological cardiac model, and 3) in ECG records from healthy subjects undergoing a tilt table test. Results:The metrics d¿, da, d¿NL, and daNL followed T-wave time- and amplitude-induced variations under different levels of noise, were strongly associated with changes in the spatio-temporal dispersion of repolarization, and showed to provide additional information to differences in the heart rate, QT and Tpe intervals, and in the T-wave width and amplitude. Conclusion: The proposed ECG-derived markers robustly quantify T-wave morphological variability, being strongly associated with changes in the dispersion of repolarization. Significance: The proposed ECG-derived markers can help to quantify the variability in the dispersion of ventricular repolarization, showing a great potential to be used as arrhythmic risk predictors in clinical situations.
000062982 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000062982 590__ $$a4.288$$b2017
000062982 591__ $$aENGINEERING, BIOMEDICAL$$b9 / 78 = 0.115$$c2017$$dQ1$$eT1
000062982 592__ $$a1.267$$b2017
000062982 593__ $$aBiomedical Engineering$$c2017$$dQ1
000062982 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000062982 700__ $$aOrini, Michele
000062982 700__ $$aDerek Tucker, J.
000062982 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000062982 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000062982 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000062982 773__ $$g64, 7 (2017), 1619-1630$$pIEEE trans. biomed. eng.$$tIEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING$$x0018-9294
000062982 8564_ $$s794915$$uhttps://zaguan.unizar.es/record/62982/files/texto_completo.pdf$$yPostprint
000062982 8564_ $$s145278$$uhttps://zaguan.unizar.es/record/62982/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000062982 909CO $$ooai:zaguan.unizar.es:62982$$particulos$$pdriver
000062982 951__ $$a2019-07-09-11:48:04
000062982 980__ $$aARTICLE