62982 20190709135504.0 doi 10.1109/TBME.2016.2614899 sideral 101483 ART-2017-101483 eng (orcid)0000-0003-4130-5866 Ramírez, Julia Universidad de Zaragoza Variability of ventricular repolarization dispersion quantified by time-warping the morphology of the T-Waves 2017 Access copy available to the general public Unrestricted Objective: We propose two electrocardiogram (ECG)-derived markers of T-wave morphological variability in the temporal, d¿, and amplitude, da, domains. Two additional markers, d¿NL and daNL, restricted to measure the nonlinear information present within d¿ and da are also proposed. Methods: We evaluated the accuracy of the proposed markers in capturing T-wave time and amplitude variations in 3 situations: 1) In a simulated set up with presence of additive Laplacian noise, 2) when modifying the spatio-temporal distribution of electrical repolarization with an electro-physiological cardiac model, and 3) in ECG records from healthy subjects undergoing a tilt table test. Results:The metrics d¿, da, d¿NL, and daNL followed T-wave time- and amplitude-induced variations under different levels of noise, were strongly associated with changes in the spatio-temporal dispersion of repolarization, and showed to provide additional information to differences in the heart rate, QT and Tpe intervals, and in the T-wave width and amplitude. Conclusion: The proposed ECG-derived markers robustly quantify T-wave morphological variability, being strongly associated with changes in the dispersion of repolarization. Significance: The proposed ECG-derived markers can help to quantify the variability in the dispersion of ventricular repolarization, showing a great potential to be used as arrhythmic risk predictors in clinical situations. info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.288 2017 ENGINEERING, BIOMEDICAL 9 / 78 = 0.115 2017 Q1 T1 1.267 2017 Biomedical Engineering 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Orini, Michele Derek Tucker, J. (orcid)0000-0002-1960-407X Pueyo, Esther Universidad de Zaragoza (orcid)0000-0003-3434-9254 Laguna, Pablo Universidad de Zaragoza 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 64, 7 (2017), 1619-1630 IEEE trans. biomed. eng. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING 0018-9294 794915 http://zaguan.unizar.es/record/62982/files/texto_completo.pdf Postprint 145278 http://zaguan.unizar.es/record/62982/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:62982 articulos driver 2019-07-09-11:48:04 ARTICLE