000062985 001__ 62985
000062985 005__ 20210121114447.0
000062985 0247_ $$2doi$$a10.1002/mabi.201500094
000062985 0248_ $$2sideral$$a90678
000062985 037__ $$aART-2015-90678
000062985 041__ $$aeng
000062985 100__ $$aJiménez-Pardo, Isabel
000062985 245__ $$aShell cross-linked polymeric micelles as Camptothecin nanocarriers for anti-HCV therapy
000062985 260__ $$c2015
000062985 5060_ $$aAccess copy available to the general public$$fUnrestricted
000062985 5203_ $$aA suitable carrier for camptothecin to act as therapy against the hepatitis C virus is presented. The carrier relies on an amphiphilic hybrid dendritic–linear–dendritic block copolymer, derived from pluronic F127 and bis-MPA dendrons, that forms micelles in aqueous solution. The dendrons admit the incorporation of multiple photoreactive groups that allow the clean and effective preparation of covalently cross-linked polymeric micelles (CLPM), susceptible of loading hydrophilic and lipophilic molecules. Cell-uptake experiments using a newly designed fluorophore, derived from rhodamine B, demonstrate that the carrier favors the accumulation of its cargo within the cell. Furthermore, loaded with camptothecin, it is efficient in fighting against the hepatitis C virus while shows lower cytotoxicity than the free drug.
000062985 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B01$$9info:eu-repo/grantAgreement/ES/DGA/B054-12$$9info:eu-repo/grantAgreement/ES/DGA/B136-13$$9info:eu-repo/grantAgreement/ES/DGA/B89$$9info:eu-repo/grantAgreement/ES/DGA/E04$$9info:eu-repo/grantAgreement/ES/FIS/PI10-00186$$9info:eu-repo/grantAgreement/ES/ISCIII/CPII13-0017$$9info:eu-repo/grantAgreement/ES/ISCIII/CP07-00289$$9info:eu-repo/grantAgreement/ES/MEC/FPU12-05210$$9info:eu-repo/grantAgreement/ES/MEC/FPU13-3870$$9info:eu-repo/grantAgreement/ES/MINECO/BFU2013-47064-P$$9info:eu-repo/grantAgreement/ES/MINECO/CTQ2012-35692$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2012-38538-C03-01
000062985 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000062985 590__ $$a3.68$$b2015
000062985 591__ $$aPOLYMER SCIENCE$$b11 / 85 = 0.129$$c2015$$dQ1$$eT1
000062985 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b90 / 289 = 0.311$$c2015$$dQ2$$eT1
000062985 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b9 / 33 = 0.273$$c2015$$dQ2$$eT1
000062985 592__ $$a1.198$$b2015
000062985 593__ $$aBioengineering$$c2015$$dQ1
000062985 593__ $$aBiomaterials$$c2015$$dQ1
000062985 593__ $$aPolymers and Plastics$$c2015$$dQ1
000062985 593__ $$aMaterials Chemistry$$c2015$$dQ1
000062985 593__ $$aBiotechnology$$c2015$$dQ1
000062985 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000062985 700__ $$0(orcid)0000-0002-5630-6645$$aGonzález-Pastor, Rebeca
000062985 700__ $$0(orcid)0000-0001-6584-6603$$aLancelot, Alexandre$$uUniversidad de Zaragoza
000062985 700__ $$aClaveria-Gimeno, Rafael
000062985 700__ $$0(orcid)0000-0001-5702-4538$$aVelázquez-Campoy, Adrián$$uUniversidad de Zaragoza
000062985 700__ $$0(orcid)0000-0001-5664-1729$$aAbian, Olga
000062985 700__ $$0(orcid)0000-0003-4416-1036$$aRos, M. Blanca$$uUniversidad de Zaragoza
000062985 700__ $$0(orcid)0000-0001-7091-077X$$aSierra, Teresa$$uUniversidad de Zaragoza
000062985 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000062985 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000062985 773__ $$g15, 10 (2015), [36 pp.]$$pMacromol. biosci.$$tMacromolecular Bioscience$$x1616-5187
000062985 8564_ $$s1351764$$uhttps://zaguan.unizar.es/record/62985/files/texto_completo.pdf$$yPostprint
000062985 8564_ $$s80743$$uhttps://zaguan.unizar.es/record/62985/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000062985 909CO $$ooai:zaguan.unizar.es:62985$$particulos$$pdriver
000062985 951__ $$a2021-01-21-10:43:47
000062985 980__ $$aARTICLE