000063025 001__ 63025
000063025 005__ 20190709135514.0
000063025 0247_ $$2doi$$a10.1186/s12886-017-0544-x
000063025 0248_ $$2sideral$$a101674
000063025 037__ $$aART-2017-101674
000063025 041__ $$aeng
000063025 100__ $$aGonzalez-Buendia, L.
000063025 245__ $$aPredictive models of long-term anatomic outcome in age-related macular degeneration treated with as-needed Ranibizumab
000063025 260__ $$c2017
000063025 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063025 5203_ $$aBackground: To analyze predictors and develop predictive models of anatomic outcome in neovascular age-related macular degeneration (AMD) treated with as-needed ranibizumab after 4 years of follow-up. Methods: A multicenter consecutive case series non-interventional study was performed. Clinical, funduscopic and OCT characteristics of 194 treatment-naïve patients with AMD treated with as-needed ranibizumab for at least 2 years and up to 4 years were analyzed at baseline, 3 months and each year until the end of the follow-up. Baseline demographic and angiographic characteristics were also evaluated. R Statistical Software was used for statistical analysis. Main outcome measure was final anatomic status. Results: Factors associated with less probability of preserved macula were diagnosis in 2009, older age, worse vision, presence of atrophy/fibrosis, pigment epithelium detachment, and geographic atrophy/fibrotic scar/neovascular AMD in the fellow eye. Factors associated with higher probability of GA were presence of atrophy and greater number of injections, whereas male sex, worse vision, lesser change in central macular thickness and presence of fibrosis were associated with less probability of GA as final macular status. Predictive model of preserved macula vs. GA/fibrotic scar showed sensibility of 77.78% and specificity of 69.09%. Predictive model of GA vs. fibrotic scar showed sensibility of 68.89% and specificity of 72.22%. Conclusions: We identified predictors of final macular status, and developed two predictive models. Predictive models that we propose are based on easily harvested variables, and, if validated, could be a useful tool for individual patient management and clinical research studies.
000063025 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063025 590__ $$a1.77$$b2017
000063025 591__ $$aOPHTHALMOLOGY$$b36 / 59 = 0.61$$c2017$$dQ3$$eT2
000063025 592__ $$a0.921$$b2017
000063025 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000063025 593__ $$aOphthalmology$$c2017$$dQ2
000063025 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063025 700__ $$aDelgado-Tirado, S.
000063025 700__ $$aSanabria, M.R.
000063025 700__ $$0(orcid)0000-0002-5077-4448$$aFernandez, I.
000063025 700__ $$aCoco, R.M.
000063025 773__ $$g17, 1 (2017), 147 [14 pp]$$pBMC OPHTHALMOLOGY$$tBMC OPHTHALMOLOGY$$x1471-2415
000063025 8564_ $$s680395$$uhttps://zaguan.unizar.es/record/63025/files/texto_completo.pdf$$yVersión publicada
000063025 8564_ $$s101108$$uhttps://zaguan.unizar.es/record/63025/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063025 909CO $$ooai:zaguan.unizar.es:63025$$particulos$$pdriver
000063025 951__ $$a2019-07-09-11:53:39
000063025 980__ $$aARTICLE