000063039 001__ 63039
000063039 005__ 20190709135519.0
000063039 0247_ $$2doi$$a10.3389/fcimb.2017.00234
000063039 0248_ $$2sideral$$a101725
000063039 037__ $$aART-2017-101725
000063039 041__ $$aeng
000063039 100__ $$0(orcid)0000-0001-7483-046X$$aEstrada-Peña, A.$$uUniversidad de Zaragoza
000063039 245__ $$aFunctional redundancy and ecological innovation shape the circulation of tick-transmitted pathogens
000063039 260__ $$c2017
000063039 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063039 5203_ $$aTicks are vectors of pathogens affecting human and animal health worldwide. Nevertheless, the ecological and evolutionary interactions between ticks, hosts, and pathogens are largely unknown. Here, we integrated a framework to evaluate the associations of the tick Ixodes ricinus with its hosts and environmental niches that impact pathogen circulation. The analysis of tick-hosts association suggested that mammals and lizards were the ancestral hosts of this tick species, and that a leap to Aves occurred around 120 M years ago. The signature of the environmental variables over the host''s phylogeny revealed the existence of two clades of vertebrates diverging along a temperature and vegetation split. This is a robust proof that the tick probably experienced a colonization of new niches by adapting to a large set of new hosts, Aves. Interestingly, the colonization of Aves as hosts did not increase significantly the ecological niche of I. ricinus, but remarkably Aves are super-spreaders of pathogens. The disparate contribution of Aves to the tick-host-pathogen networks revealed that I. ricinus evolved to maximize habitat overlap with some hosts that are super-spreaders of pathogens. These results supported the hypothesis that large host networks are not a requirement of tick survival but pathogen circulation. The biological cost of tick adaptation to non-optimal environmental conditions might be balanced by molecular mechanisms triggered by the pathogens that we have only begun to understand.
000063039 536__ $$9info:eu-repo/grantAgreement/EC/FP7/278976/EU/ANTIcipating the Global Onset of Novel Epidemics/ANTIGONE$$9info:eu-repo/grantAgreement/EUR/COST/TD1303
000063039 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063039 590__ $$a3.52$$b2017
000063039 591__ $$aMICROBIOLOGY$$b40 / 125 = 0.32$$c2017$$dQ2$$eT1
000063039 591__ $$aIMMUNOLOGY$$b64 / 155 = 0.413$$c2017$$dQ2$$eT2
000063039 592__ $$a1.703$$b2017
000063039 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000063039 593__ $$aInfectious Diseases$$c2017$$dQ1
000063039 593__ $$aMicrobiology (medical)$$c2017$$dQ1
000063039 593__ $$aMicrobiology$$c2017$$dQ1
000063039 593__ $$aImmunology$$c2017$$dQ2
000063039 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063039 700__ $$ade la Fuente, J.
000063039 700__ $$aCabezas-Cruz, A.
000063039 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000063039 773__ $$g7, MAY (2017), 234 [11 pp]$$tFrontiers in cellular and infection microbiology$$x2235-2988
000063039 8564_ $$s265544$$uhttps://zaguan.unizar.es/record/63039/files/texto_completo.pdf$$yVersión publicada
000063039 8564_ $$s12083$$uhttps://zaguan.unizar.es/record/63039/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063039 909CO $$ooai:zaguan.unizar.es:63039$$particulos$$pdriver
000063039 951__ $$a2019-07-09-11:56:30
000063039 980__ $$aARTICLE