63039 20190709135519.0 doi 10.3389/fcimb.2017.00234 sideral 101725 ART-2017-101725 eng (orcid)0000-0001-7483-046X Estrada-Peña, A. Universidad de Zaragoza Functional redundancy and ecological innovation shape the circulation of tick-transmitted pathogens 2017 Access copy available to the general public Unrestricted Ticks are vectors of pathogens affecting human and animal health worldwide. Nevertheless, the ecological and evolutionary interactions between ticks, hosts, and pathogens are largely unknown. Here, we integrated a framework to evaluate the associations of the tick Ixodes ricinus with its hosts and environmental niches that impact pathogen circulation. The analysis of tick-hosts association suggested that mammals and lizards were the ancestral hosts of this tick species, and that a leap to Aves occurred around 120 M years ago. The signature of the environmental variables over the host''s phylogeny revealed the existence of two clades of vertebrates diverging along a temperature and vegetation split. This is a robust proof that the tick probably experienced a colonization of new niches by adapting to a large set of new hosts, Aves. Interestingly, the colonization of Aves as hosts did not increase significantly the ecological niche of I. ricinus, but remarkably Aves are super-spreaders of pathogens. The disparate contribution of Aves to the tick-host-pathogen networks revealed that I. ricinus evolved to maximize habitat overlap with some hosts that are super-spreaders of pathogens. These results supported the hypothesis that large host networks are not a requirement of tick survival but pathogen circulation. The biological cost of tick adaptation to non-optimal environmental conditions might be balanced by molecular mechanisms triggered by the pathogens that we have only begun to understand. info:eu-repo/grantAgreement/EC/FP7/278976/EU/ANTIcipating the Global Onset of Novel Epidemics/ANTIGONE info:eu-repo/grantAgreement/EUR/COST/TD1303 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.52 2017 MICROBIOLOGY 40 / 125 = 0.32 2017 Q2 T1 IMMUNOLOGY 64 / 155 = 0.413 2017 Q2 T2 1.703 2017 Medicine (miscellaneous) 2017 Q1 Infectious Diseases 2017 Q1 Microbiology (medical) 2017 Q1 Microbiology 2017 Q1 Immunology 2017 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion de la Fuente, J. Cabezas-Cruz, A. 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 7, MAY (2017), 234 [11 pp] Frontiers in cellular and infection microbiology 2235-2988 265544 http://zaguan.unizar.es/record/63039/files/texto_completo.pdf Versión publicada 12083 http://zaguan.unizar.es/record/63039/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:63039 articulos driver 2019-07-09-11:56:30 ARTICLE