63058 20200729203741.0 doi 10.1007/s10237-016-0841-y sideral 96684 ART-2017-96684 eng (orcid)0000-0002-6134-8698 Sierra, M. Universidad de Zaragoza Predicting muscle fatigue: a response surface approximation based on proper generalized decomposition technique 2017 Access copy available to the general public Unrestricted A novel technique is proposed to predict force reduction in skeletal muscle due to fatigue under the influence of electrical stimulus parameters and muscle physiological characteristics. Twelve New Zealand white rabbits were divided in four groups ((Formula presented.)) to obtain the active force evolution of in vitro Extensor Digitorum Longus muscles for an hour of repeated contractions under different electrical stimulation patterns. Left and right muscles were tested, and a total of 24 samples were used to construct a response surface based in the proper generalized decomposition. After the response surface development, one additional rabbit was used to check the predictive potential of the technique. This multidimensional surface takes into account not only the decay of the maximum repeated peak force, but also the shape evolution of each contraction, muscle weight, electrical input signal and stimulation protocol. This new approach of the fatigue simulation challenge allows to predict, inside the multispace surface generated, the muscle response considering other stimulation patterns, different tissue weight, etc. info:eu-repo/grantAgreement/ES/DGA/T88 info:eu-repo/grantAgreement/ES/MINECO/DPI2014-54981-R info:eu-repo/grantAgreement/ES/UZ/JIUZ-2013-TEC-09 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.212 2017 ENGINEERING, BIOMEDICAL 20 / 78 = 0.256 2017 Q2 T1 BIOPHYSICS 22 / 72 = 0.306 2017 Q2 T1 1.138 2017 Biotechnology 2017 Q1 Modeling and Simulation 2017 Q1 Mechanical Engineering 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0002-6870-0594 Grasa, J. Universidad de Zaragoza (orcid)0000-0001-8301-6902 Muñoz, M. J. Universidad de Zaragoza (orcid)0000-0001-5981-5448 Miana-Mena, F. Universidad de Zaragoza (orcid)0000-0003-3003-5856 González, D. Universidad de Zaragoza 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 1005 315 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Farmacología 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 16, 625-634 (2017), 1-10 Biomech. model. mechanobiol. BIOMECHANICS AND MODELING IN MECHANOBIOLOGY 1617-7959 1292883 http://zaguan.unizar.es/record/63058/files/texto_completo.pdf Postprint 98539 http://zaguan.unizar.es/record/63058/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:63058 articulos driver 2020-07-29-20:19:56 ARTICLE