doi:10.1039/c7nj01822cengFratila, Raluca M.Navascuez, MarcosIdiago-López, JavierEzeiza, MaiteMiranda, José I.Aizpurua, Jesús M.Martínez de la Fuente, JesúsCovalent immobilisation of magnetic nanoparticles on surfaces via strain-­promoted azide-­alkyne click chemistryART-2017-100648Herein we report the synthesis of “clickable” magnetic nanoparticles (MNPs) stable in suspension in physiological media for bioorthogonal click chemistry applications. These MNPs incorporate into their coating a cyclooctynyl derivative for strain-promoted azide–alkyne (SPAAC) cycloaddition and either a polyethylene glycol or a glucose moiety to ensure MNP stability in physiological media. Their reactivity towards azide-functionalised Si surfaces was investigated, demonstrating their potential as bioorthogonal probes.2017http://zaguan.unizar.es/record/6306010.1039/c7nj01822chttp://zaguan.unizar.es/record/63060oai:zaguan.unizar.es:63060info:eu-repo/grantAgreement/ES/UZ/JIUZ-2015-CIE-03info:eu-repo/grantAgreement/ES/MINECO/SAF2014-54763-C2-2-RThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 657215-OUTstandINginfo:eu-repo/grantAgreement/EC/H2020/657215/EU/Cell-surface immobilized vs. internalized magnetic nanoparticles for magnetic hyperthermia studies/OUTstandINgNEW JOURNAL OF CHEMISTRY 19 (2017), [6 pp.]by-nc-ndhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccess