000063106 001__ 63106
000063106 005__ 20181123104100.0
000063106 0247_ $$2doi$$a10.1109/CIC.2015.7411050
000063106 0248_ $$2sideral$$a94697
000063106 037__ $$aART-2016-94697
000063106 041__ $$aeng
000063106 100__ $$aMonasterio, Violeta
000063106 245__ $$aThe role of purkinje automaticity as an arrhythmia mechanism in hyperkalaemia
000063106 260__ $$c2016
000063106 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063106 5203_ $$aThe pacemaker activity of Purkinje (PK) cells is usually suppressed by the sino-atrial (SA) node. Under abnormal conditions, PK cells may produce ectopic focal activity leading to tachycardia and fibrillation. This computational modelling work illustrates the potential role of PK automaticity as an arrhythmia mechanism in hyperkalaemia. First, we investigated the automaticity of isolated PK cells under hyperkalaemic conditions. Second, the potential consequences of altered PK automaticity were explored in a 1-D model of a terminal PK fibre running through a hyperkalaemic zone. Hyperkalaemia was found to accelerate the autorhythmic period of isolated PK cells with respect to control. For extracellular potassium levels = 7.2 mM, spontaneous action potentials (APs) appeared in the PK fibre, leading to conduction disturbances and complex combinations of spontaneous and stimulation-driven APs.
000063106 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T88$$9info:eu-repo/grantAgreement/ES/DGA/T96$$9info:eu-repo/grantAgreement/ES/MINECO/TIN2012-37546-C03-03$$9info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R
000063106 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063106 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion
000063106 700__ $$0(orcid)0000-0001-7789-2973$$aCarro, Jesús
000063106 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, Esther$$uUniversidad de Zaragoza
000063106 700__ $$0(orcid)0000-0001-7612-266X$$aRodríguez, José F.$$uUniversidad de Zaragoza
000063106 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000063106 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000063106 773__ $$g42 (2016), 873-876$$pComput. cardiol.$$tComputing in Cardiology$$x2325-8861
000063106 8564_ $$s1085915$$uhttps://zaguan.unizar.es/record/63106/files/texto_completo.pdf$$yVersión publicada
000063106 8564_ $$s8427$$uhttps://zaguan.unizar.es/record/63106/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063106 909CO $$ooai:zaguan.unizar.es:63106$$particulos$$pdriver
000063106 951__ $$a2018-11-23-10:32:51
000063106 980__ $$aARTICLE