000063117 001__ 63117
000063117 005__ 20181123104107.0
000063117 0248_ $$2sideral$$a98544
000063117 037__ $$aART-2016-98544
000063117 041__ $$aeng
000063117 100__ $$0(orcid)0000-0003-0226-4950$$aMartin-Yebra, Alba
000063117 245__ $$aIndex of T-wave variation as a predictor of sudden cardiac death in chronic heart failure patients with atrial fibrillation
000063117 260__ $$c2016
000063117 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063117 5203_ $$aChronic heart failure (CHF) and atrial fibrillation (AF) are worldwide leading causes of morbidity and mortality in elders, a large part due to sudden cardiac deaths (SCD). The high irregularity of ventricular response in AF patients makes the use of standard SCD-risk markers inappropriate in this target population. The aim of this study was twofold: i) to propose a new index, suitable for AF patients, able to quantify ventricular repolarization changes; and ii) to evaluate its prognostic value in a CHF population with AF. Holter ECG recordings from 176 consecutive CHF patients with AF (22 SCD) were analyzed. The index of T-wave variation (ITV), quantifying the average T-wave changes in pairs of consecutive beats under stable rhythm conditions, was computed using a fully-automatic method. Survival analysis was performed considering SCD as an independent endpoint. ITV was higher for SCD than non-SCD victims (median (Q1;Q3): 24.9 (14.4;85.4) µV vs 17.1 (11.3;28.2) µV, p=0.06). In a survival analysis where the threshold was set on the third quartile of ITV values, ITV (+) outcome was successfully associated to SCD (Hazard Ratio (CI):3.22 (1.36, 7.58)per µV, p=0.008). In conclusion, we show in this work that Ijy stratifies CHF patients with AF according to their risk of SCD, with larger ITV associated to lower survival probability.
000063117 536__ $$9info:eu-repo/grantAgreement/ES/DGA/T96$$9info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R
000063117 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063117 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063117 700__ $$aCygankiewicz, Iwona
000063117 700__ $$aBayés-De-Luna, Antoni
000063117 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, Pablo$$uUniversidad de Zaragoza
000063117 700__ $$aCaiani, Enrico G.
000063117 700__ $$0(orcid)0000-0002-7503-3339$$aMartinez, Juan Pablo$$uUniversidad de Zaragoza
000063117 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000063117 773__ $$g43 (2016), 5-8$$pComput. cardiol.$$tComputing in Cardiology$$x2325-8861
000063117 85641 $$uhttp://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=7868665$$zTexto completo de la revista
000063117 8564_ $$s156890$$uhttps://zaguan.unizar.es/record/63117/files/texto_completo.pdf$$yVersión publicada
000063117 8564_ $$s114139$$uhttps://zaguan.unizar.es/record/63117/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063117 909CO $$ooai:zaguan.unizar.es:63117$$particulos$$pdriver
000063117 951__ $$a2018-11-23-10:33:20
000063117 980__ $$aARTICLE