63117 20181123104107.0 sideral 98544 ART-2016-98544 eng (orcid)0000-0003-0226-4950 Martin-Yebra, Alba Index of T-wave variation as a predictor of sudden cardiac death in chronic heart failure patients with atrial fibrillation 2016 Access copy available to the general public Unrestricted Chronic heart failure (CHF) and atrial fibrillation (AF) are worldwide leading causes of morbidity and mortality in elders, a large part due to sudden cardiac deaths (SCD). The high irregularity of ventricular response in AF patients makes the use of standard SCD-risk markers inappropriate in this target population. The aim of this study was twofold: i) to propose a new index, suitable for AF patients, able to quantify ventricular repolarization changes; and ii) to evaluate its prognostic value in a CHF population with AF. Holter ECG recordings from 176 consecutive CHF patients with AF (22 SCD) were analyzed. The index of T-wave variation (ITV), quantifying the average T-wave changes in pairs of consecutive beats under stable rhythm conditions, was computed using a fully-automatic method. Survival analysis was performed considering SCD as an independent endpoint. ITV was higher for SCD than non-SCD victims (median (Q1;Q3): 24.9 (14.4;85.4) µV vs 17.1 (11.3;28.2) µV, p=0.06). In a survival analysis where the threshold was set on the third quartile of ITV values, ITV (+) outcome was successfully associated to SCD (Hazard Ratio (CI):3.22 (1.36, 7.58)per µV, p=0.008). In conclusion, we show in this work that Ijy stratifies CHF patients with AF according to their risk of SCD, with larger ITV associated to lower survival probability. info:eu-repo/grantAgreement/ES/DGA/T96 info:eu-repo/grantAgreement/ES/MINECO/TEC2013-42140-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Cygankiewicz, Iwona Bayés-De-Luna, Antoni (orcid)0000-0003-3434-9254 Laguna, Pablo Universidad de Zaragoza Caiani, Enrico G. (orcid)0000-0002-7503-3339 Martinez, Juan Pablo Universidad de Zaragoza 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 43 (2016), 5-8 Comput. cardiol. Computing in Cardiology 2325-8861 http://ieeexplore.ieee.org/stamp/stamp.jsp?arnumber=7868665 Texto completo de la revista 156890 http://zaguan.unizar.es/record/63117/files/texto_completo.pdf Versión publicada 114139 http://zaguan.unizar.es/record/63117/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:63117 articulos driver 2018-11-23-10:33:20 ARTICLE