000063198 001__ 63198
000063198 005__ 20190709135513.0
000063198 0247_ $$2doi$$a10.3389/fcimb.2017.00405
000063198 0248_ $$2sideral$$a101910
000063198 037__ $$aART-2017-101910
000063198 041__ $$aeng
000063198 100__ $$0(orcid)0000-0001-7483-046X$$aEstrada-Peña, Agustín$$uUniversidad de Zaragoza
000063198 245__ $$aHost distribution does not limit the range of the tick ixodes ricinus but impacts the circulation of transmitted pathogens
000063198 260__ $$c2017
000063198 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063198 5203_ $$aTicks, pathogens, and vertebrates interact in a background of environmental features that regulate the densities of ticks and vertebrates, affecting their contact rates and thence the circulation of the pathogens. Regional scale studies are invaluable sources of information about the regulation of these interactions, but a large-scale analysis of the interaction of communities of ticks, hosts, and the environment has been never modeled. This study builds on network analysis, satellite-derived climate and vegetation, and environmental modeling, quantifying the interactions between the tick Ixodes ricinus and the transmitted bacteria of the complex Borrelia burgdorferi s.l. in the Western Palaearctic. We derived the rates of contact of the tick with 162 species of vertebrates recorded as hosts, and the relative importance of each vertebrate in the circulation of the pathogen. We compiled more than 11 millions of pairs of coordinates of the vertebrates, deriving distribution models of each species and the relative faunal composition in the target territory. The results of the modeling of the distribution of the tick and its hosts, weighted by their importance in the circulation of Borrelia captured the spatial patterns of interactions that allow the circulation of the pathogen. Results indicate that both I. ricinus and B. burgdorferi s.l. are supported in the Western Palaearctic by complex communities of vertebrates, which have large distribution ranges. This high functional redundancy results in the pervasiveness of B. burgdorferi s.l., which depends on the gradient of contributions of the large community of vertebrates, instead of relying on a few dominant vertebrates, which was the prevailing paradigm. Most prominent reservoirs of the pathogen are distributed in specific regions of the environmental niche. However, literally dozens of potential reservoirs can colonize many other environmental regions, marginally but efficiently contributing to the circulation of the pathogen. These results consistently point to the need of evaluating the beta-diversity of the community of vertebrates acting as reservoirs of the pathogen to better know the interactions with the vector. They also demonstrate why the pathogen is so resilient to perturbations in the composition of the reservoirs.
000063198 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063198 590__ $$a3.52$$b2017
000063198 591__ $$aMICROBIOLOGY$$b40 / 125 = 0.32$$c2017$$dQ2$$eT1
000063198 591__ $$aIMMUNOLOGY$$b64 / 155 = 0.413$$c2017$$dQ2$$eT2
000063198 592__ $$a1.703$$b2017
000063198 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000063198 593__ $$aInfectious Diseases$$c2017$$dQ1
000063198 593__ $$aMicrobiology (medical)$$c2017$$dQ1
000063198 593__ $$aMicrobiology$$c2017$$dQ1
000063198 593__ $$aImmunology$$c2017$$dQ2
000063198 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063198 700__ $$aFuente, José de la
000063198 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000063198 773__ $$g7 (2017), 1-10$$tFrontiers in cellular and infection microbiology$$x2235-2988
000063198 8564_ $$s3017921$$uhttps://zaguan.unizar.es/record/63198/files/texto_completo.pdf$$yVersión publicada
000063198 8564_ $$s12114$$uhttps://zaguan.unizar.es/record/63198/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063198 909CO $$ooai:zaguan.unizar.es:63198$$particulos$$pdriver
000063198 951__ $$a2019-07-09-11:53:17
000063198 980__ $$aARTICLE