63206 20190709135517.0 doi 10.1371/journal.pone.0185889 sideral 101948 ART-2017-101948 eng Perrotti, P.P. Genetic variation associated with cardiovascular risk in autoimmune diseases 2017 Access copy available to the general public Unrestricted Autoimmune diseases have a higher prevalence of cardiovascular events compared to the general population. The objective of this study was to investigate the genetic basis of cardiovascular disease (CVD) risk in autoimmunity. We analyzed genome-wide genotyping data from 6, 485 patients from six autoimmune diseases that are associated with a high socioeconomic impact. First, for each disease, we tested the association of established CVD risk loci. Second, we analyzed the association of autoimmune disease susceptibility loci with CVD. Finally, to identify genetic patterns associated with CVD risk, we applied the cross-phenotype meta-analysis approach (CPMA) on the genome-wide data. A total of 17 established CVD risk loci were significantly associated with CVD in the autoimmune patient cohorts. From these, four loci were found to have significantly different genetic effects across autoimmune diseases. Six autoimmune susceptibility loci were also found to be associated with CVD risk. Genome-wide CPMA analysis identified 10 genetic clusters strongly associated with CVD risk across all autoimmune diseases. Two of these clusters are highly enriched in pathways previously associated with autoimmune disease etiology (TNFa and IFN¿ cytokine pathways). The results of this study support the presence of specific genetic variation associated with the increase of CVD risk observed in autoimmunity. info:eu-repo/grantAgreement/ES/MINECO/IPT-010000-2010-36 info:eu-repo/grantAgreement/ES/MINECO/PSE-010000-2006-6 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 2.766 2017 MULTIDISCIPLINARY SCIENCES 15 / 64 = 0.234 2017 Q1 T1 1.164 2017 Agricultural and Biological Sciences (miscellaneous) 2017 Q1 Medicine (miscellaneous) 2017 Q1 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Aterido, A. Fernández-Nebro, A. Cañete, J.D. Ferrándiz, C. Tornero, J. Gisbert, J.P. Domènech, E. Fernández-Gutiérrez, B. (orcid)0000-0003-0076-3529 Gomollón, Fernando Universidad de Zaragoza García-Planella, E. Fernández, E. Sanmartí, R. Gratacós, J. Martínez-Taboada, V.M. Rodríguez-Rodríguez, L. Palau, N. Tortosa, R. Corbeto, M.L. Lasanta, M.L. Marsal, S. Julià, A. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 12, 10 (2017), e0185889 PLoS One PloS one 1932-6203 1980914 http://zaguan.unizar.es/record/63206/files/texto_completo.pdf Versión publicada 108199 http://zaguan.unizar.es/record/63206/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:63206 articulos driver 2019-07-09-11:56:00 ARTICLE