63278 20171129112116.0 doi 10.1038/ncomms4025 sideral 85754 ART-2014-85754 eng (orcid)0000-0001-5559-8757 Fratila, Raluca M. Universidad de Zaragoza Multinuclear nanoliter one-dimensional and two-dimensional NMR spectroscopy with a single non-resonant microcoil 2014 Access copy available to the general public Unrestricted Nuclear magnetic resonance (NMR) spectroscopy is a powerful analytical technique, but its low sensitivity and highly sophisticated, costly, equipment severely constrain more widespread applications. Here we show that a non-resonant planar transceiver microcoil integrated in a microfluidic chip (detection volume 25¿nl) can detect different nuclides in the full broad-band range of Larmor frequencies (at 9.4¿T from 61 to 400¿MHz). Routine one-dimensional (1D) and two-dimensional (2D), homo- and heteronuclear experiments can be carried out using the broad-band coil set-up. Noteworthy, heteronuclear 2D experiments can be performed in a straightforward manner on virtually any combination of nuclides (from classical 1H–13C to more exotic combinations like 19F–31P) both in coupled and decoupled mode. Importantly, the concept of a non-resonant system provides magnetic field-independent NMR probes; moreover, the small-volume alleviates problems related to field inhomogeneity, making the broad-band coil an attractive option for, for example, portable and table-top NMR systems. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 11.47 2014 MULTIDISCIPLINARY SCIENCES 3 / 57 = 0.053 2014 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gomez, M. Victoria Sykora, Stanislav Velders, Aldrik H. 2013 765 Universidad de Zaragoza Departamento de Química Orgánica Química Orgánica 5, 3025 (2014), 1-8 NATURE COMMUNICATIONS NATURE COMMUNICATIONS 2041-1723 466365 http://zaguan.unizar.es/record/63278/files/texto_completo.pdf Versión publicada 64749 http://zaguan.unizar.es/record/63278/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:63278 articulos driver 2017-11-28-12:45:14 ARTICLE