63282 20210121114505.0 doi 10.1039/c5ra05383h sideral 101184 ART-2015-101184 eng (orcid)0000-0002-0769-7168 Alegre-Requena, Juan V. One-pot synthesis of unsymmetrical squaramides 2015 Access copy available to the general public Unrestricted The results concerning the first one-pot synthesis of unsymmetrical squaramides are reported. This straightforward procedure allows appealing and commonly used squaramide derivatives to be obtained with very good results. The methodology developed in this work saves energy, eliminates the purification steps for intermediate products, reduces costs and leads to better yields compared to those obtained through the traditional “stop-and-go” approach. Moreover, we have proved the efficiency of our process with the synthesis of three biologically active structures, improving the results of the previously reported stepwise syntheses. Interestingly, this simple and cheap method could attract the interest of pharmaceutical and chemical companies aiming to produce these active compounds on a large scale. info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 3.289 2015 CHEMISTRY, MULTIDISCIPLINARY 48 / 163 = 0.294 2015 Q2 T1 0.947 2015 Chemistry (miscellaneous) 2015 Q1 Chemical Engineering (miscellaneous) 2015 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion (orcid)0000-0001-6832-8983 Marqués-López, Eugenia Universidad de Zaragoza (orcid)0000-0002-5244-9569 Herrera, Raquel P. Universidad de Zaragoza 2013 765 Universidad de Zaragoza Dpto. Química Orgánica Área Química Orgánica 5 (2015), [15 pp.] RSC ADVANCES RSC Advances 2046-2069 550397 http://zaguan.unizar.es/record/63282/files/texto_completo.pdf Postprint 91047 http://zaguan.unizar.es/record/63282/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:63282 articulos driver 2021-01-21-10:53:54 ARTICLE