000063297 001__ 63297
000063297 005__ 20180309150124.0
000063297 0247_ $$2doi$$a10.1371/journal.pone.0058476
000063297 0248_ $$2sideral$$a81307
000063297 037__ $$aART-2013-81307
000063297 041__ $$aeng
000063297 100__ $$aFayed, N.
000063297 245__ $$aBrain Changes in Long-Term Zen Meditators Using Proton Magnetic Resonance Spectroscopy and Diffusion Tensor Imaging: A Controlled Study
000063297 260__ $$c2013
000063297 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063297 5203_ $$aIntroduction: This work aimed to determine whether 1H magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), diffusion-weighted imaging (DWI) and diffusion tensor imaging (DTI) are correlated with years of meditation and psychological variables in long-term Zen meditators compared to healthy non-meditator controls.
Materials and Methods: Design. Controlled, cross-sectional study. Sample. Meditators were recruited from a Zen Buddhist monastery. The control group was recruited from hospital staff. Meditators were administered questionnaires on anxiety, depression, cognitive impairment and mindfulness. 1H-MRS (1.5 T) of the brain was carried out by exploring four areas: both thalami, both hippocampi, the posterior superior parietal lobule (PSPL) and posterior cingulate gyrus. Predefined areas of the brain were measured for diffusivity (ADC) and fractional anisotropy (FA) by MR-DTI.
Results: Myo-inositol (mI) was increased in the posterior cingulate gyrus and Glutamate (Glu), N-acetyl-aspartate (NAA) and N-acetyl-aspartate/Creatine (NAA/Cr) was reduced in the left thalamus in meditators. We found a significant positive correlation between mI in the posterior cingulate and years of meditation (r¿=¿0.518; p¿=¿.019). We also found significant negative correlations between Glu (r¿=¿-0.452; p¿=¿.045), NAA (r¿=¿-0.617; p¿=¿.003) and NAA/Cr (r¿=¿-0.448; P¿=¿.047) in the left thalamus and years of meditation. Meditators showed a lower Apparent Diffusion Coefficient (ADC) in the left posterior parietal white matter than did controls, and the ADC was negatively correlated with years of meditation (r¿=¿-0.4850, p¿=¿.0066).
Conclusions: The results are consistent with the view that mI, Glu and NAA are the most important altered metabolites. This study provides evidence of subtle abnormalities in neuronal function in regions of the white matter in meditators.
000063297 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063297 590__ $$a3.534$$b2013
000063297 591__ $$aMULTIDISCIPLINARY SCIENCES$$b8 / 56 = 0.143$$c2013$$dQ1$$eT1
000063297 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063297 700__ $$0(orcid)0000-0002-1690-4130$$aLopez del Hoyo, Y.$$uUniversidad de Zaragoza
000063297 700__ $$aAndres, E.
000063297 700__ $$aSerrano-Blanco, A.
000063297 700__ $$aBellón, J.
000063297 700__ $$aAguilar, K.
000063297 700__ $$aCebolla, A.
000063297 700__ $$0(orcid)0000-0002-3797-4218$$aGarcia-Campayo, J.$$uUniversidad de Zaragoza
000063297 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDepartamento de Medicina, Psiquiatría y Dermatología$$cPsiquiatría
000063297 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDepartamento de Psicología y Sociología$$cPsicología Básica
000063297 773__ $$g8, 3 (2013), e58476 [14 pp]$$pPLoS One$$tPLoS One$$x1932-6203
000063297 8564_ $$s561031$$uhttps://zaguan.unizar.es/record/63297/files/texto_completo.pdf$$yVersión publicada
000063297 8564_ $$s118985$$uhttps://zaguan.unizar.es/record/63297/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063297 909CO $$ooai:zaguan.unizar.es:63297$$particulos$$pdriver
000063297 951__ $$a2018-03-09-14:57:05
000063297 980__ $$aARTICLE