000063309 001__ 63309
000063309 005__ 20171129112117.0
000063309 0247_ $$2doi$$a10.1371/journal.pone.0078205
000063309 0248_ $$2sideral$$a85925
000063309 037__ $$aART-2013-85925
000063309 041__ $$aeng
000063309 100__ $$aEchenique-Robba, P.
000063309 245__ $$aReducing the standard deviation in multiple-assay experiments where the variation matters but the absolute value does not
000063309 260__ $$c2013
000063309 5060_ $$aAccess copy available to the general public$$fUnrestricted
000063309 5203_ $$aWhen the value of a quantity for a number of systems (cells, molecules, people, chunks of metal, DNA vectors, so on) is measured and the aim is to replicate the whole set again for different trials or assays, despite the efforts for a near-equal design, scientists might often obtain quite different measurements. As a consequence, some systems’ averages present standard deviations that are too large to render statistically significant results. This work presents a novel correction method of a very low mathematical and numerical complexity that can reduce the standard deviation of such results and increase their statistical significance. Two conditions are to be met: the inter-system variations of matter while its absolute value does not, and a similar tendency in the values of must be present in the different assays (or in other words, the results corresponding to different assays must present a high linear correlation). We demonstrate the improvements this method offers with a cell biology experiment, but it can definitely be applied to any problem that conforms to the described structure and requirements and in any quantitative scientific field that deals with data subject to uncertainty.
000063309 536__ $$9info:eu-repo/grantAgreement/ES/MICINN/BFU2009-11800$$9info:eu-repo/grantAgreement/ES/MICINN/FIS2009-13364-C02-01$$9info:eu-repo/grantAgreement/ES/UZ/FPUZ-2010-BIO-03$$9info:eu-repo/grantAgreement/ES/UZ/UZ2011-BIO-02
000063309 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000063309 590__ $$a3.534$$b2013
000063309 591__ $$aMULTIDISCIPLINARY SCIENCES$$b8 / 56 = 0.143$$c2013$$dQ1$$eT1
000063309 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000063309 700__ $$aNelo-Bazán, M.A.
000063309 700__ $$0(orcid)0000-0003-0062-1029$$aCarrodeguas, J.A.$$uUniversidad de Zaragoza
000063309 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDepartamento de Bioquímica y Biología Molecular y Celular$$cBioquímica y Biología Molecular
000063309 773__ $$g8, 10 (2013), e78205 [11 pp.]$$pPLoS One$$tPLoS One$$x1932-6203
000063309 8564_ $$s889623$$uhttps://zaguan.unizar.es/record/63309/files/texto_completo.pdf$$yVersión publicada
000063309 8564_ $$s123206$$uhttps://zaguan.unizar.es/record/63309/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000063309 909CO $$ooai:zaguan.unizar.es:63309$$particulos$$pdriver
000063309 951__ $$a2017-11-28-12:46:27
000063309 980__ $$aARTICLE