63309 20171129112117.0 doi 10.1371/journal.pone.0078205 sideral 85925 ART-2013-85925 eng Echenique-Robba, P. Reducing the standard deviation in multiple-assay experiments where the variation matters but the absolute value does not 2013 Access copy available to the general public Unrestricted When the value of a quantity for a number of systems (cells, molecules, people, chunks of metal, DNA vectors, so on) is measured and the aim is to replicate the whole set again for different trials or assays, despite the efforts for a near-equal design, scientists might often obtain quite different measurements. As a consequence, some systems’ averages present standard deviations that are too large to render statistically significant results. This work presents a novel correction method of a very low mathematical and numerical complexity that can reduce the standard deviation of such results and increase their statistical significance. Two conditions are to be met: the inter-system variations of matter while its absolute value does not, and a similar tendency in the values of must be present in the different assays (or in other words, the results corresponding to different assays must present a high linear correlation). We demonstrate the improvements this method offers with a cell biology experiment, but it can definitely be applied to any problem that conforms to the described structure and requirements and in any quantitative scientific field that deals with data subject to uncertainty. info:eu-repo/grantAgreement/ES/MICINN/BFU2009-11800 info:eu-repo/grantAgreement/ES/MICINN/FIS2009-13364-C02-01 info:eu-repo/grantAgreement/ES/UZ/FPUZ-2010-BIO-03 info:eu-repo/grantAgreement/ES/UZ/UZ2011-BIO-02 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.534 2013 MULTIDISCIPLINARY SCIENCES 8 / 56 = 0.143 2013 Q1 T1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Nelo-Bazán, M.A. (orcid)0000-0003-0062-1029 Carrodeguas, J.A. Universidad de Zaragoza 1002 060 Universidad de Zaragoza Departamento de Bioquímica y Biología Molecular y Celular Bioquímica y Biología Molecular 8, 10 (2013), e78205 [11 pp.] PLoS One PLoS One 1932-6203 889623 http://zaguan.unizar.es/record/63309/files/texto_completo.pdf Versión publicada 123206 http://zaguan.unizar.es/record/63309/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:63309 articulos driver 2017-11-28-12:46:27 ARTICLE