doi:10.1039/C5CE02526EengAlegre-Requena, Juan V.Marqués-López, María EugeniaHerrera, Raquel P.Díaz Díaz, DavidMetal-organic frameworks (MOFs) bring new life to hydrogen-bonding organocatalysts in confined spacesART-2016-101186Hydrogen-bonding organocatalysis has emerged as a promising biomimetic alternative to Lewis acid catalysis. Urea, thiourea and squaramide moieties represent the most common hydrogen-bond donors used for the preparation of these catalysts. However, their significant tendency to undergo self-quenching (self-aggregation) often decreases their solubility and reactivity. Recently, scientists have found a promising way around this problem by immobilizing the hydrogen-bonding organocatalysts on metal–organic frameworks (MOFs). Along with advantageous modular synthesis and recycling properties, the tunable porosity and topology of MOFs also allows fast mass transport and/or interactions with substrates. Herein, we highlight the existing examples dealing with the fabrication and testing of hydrogen-bonding organocatalyst-containing MOFs, providing also our vision for further advances in this area. The results derived from these studies will likely serve as inspiration for the future development of superior hydrogen-bonding organocatalysts to accomplish in confined spaces chemical transformations that are either slow or unaffordable under standard homogeneous conditions.2016http://zaguan.unizar.es/record/6334510.1039/C5CE02526Ehttp://zaguan.unizar.es/record/63345oai:zaguan.unizar.es:63345info:eu-repo/grantAgreement/ES/CSIC/PIE-201580I010info:eu-repo/grantAgreement/ES/DGA/E104info:eu-repo/grantAgreement/ES/UZ/JIUZ-2014-CIE-07CRYSTENGCOMM 18, 22 (2016), 3985-3995All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/openAccess