000063346 001__ 63346 000063346 005__ 20171129112118.0 000063346 0247_ $$2doi$$a10.1038/ncomms3776 000063346 0248_ $$2sideral$$a84153 000063346 037__ $$aART-2013-84153 000063346 041__ $$aeng 000063346 100__ $$aGudmundsson, J. 000063346 245__ $$aA common variant at 8q24.21 is associated with renal cell cancer 000063346 260__ $$c2013 000063346 5060_ $$aAccess copy available to the general public$$fUnrestricted 000063346 5203_ $$aRenal cell carcinoma (RCC) represents between 80 and 90% of kidney cancers. Previous genome-wide association studies of RCC have identified five variants conferring risk of the disease. Here we report the results from a discovery RCC genome-wide association study and replication analysis, including a total of 2,411 patients and 71,497 controls. One variant, rs35252396[CG] located at 8q24.21, is significantly associated with RCC after combining discovery and replication results (OR=1.27, Pcombined=5.4 × 10-11) and has an average risk allele frequency in controls of 46%. rs35252396[CG] does not have any strongly correlated variants in the genome and is located within a region predicted to have regulatory functions in several cell lines, including six originating from the kidney. This is the first RCC variant reported at 8q24.21 and it is largely independent (r2=0.02) of the numerous previously reported cancer risk variants at this locus. 000063346 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000063346 590__ $$a10.742$$b2013 000063346 591__ $$aMULTIDISCIPLINARY SCIENCES$$b3 / 56 = 0.054$$c2013$$dQ1$$eT1 000063346 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000063346 700__ $$aSulem, P. 000063346 700__ $$aGudbjartsson, D.F. 000063346 700__ $$aMasson, G. 000063346 700__ $$aPetursdottir, V. 000063346 700__ $$aHardarson, S. 000063346 700__ $$aGudjonsson, S.A. 000063346 700__ $$aJohannsdottir, H. 000063346 700__ $$aHelgadottir, H.T. 000063346 700__ $$aStacey, S.N. 000063346 700__ $$aMagnusson, O.T. 000063346 700__ $$aHelgason, H. 000063346 700__ $$aPanadero, A. 000063346 700__ $$aVan, Der Zanden 000063346 700__ $$aAben, K.K.H. 000063346 700__ $$aVermeulen, S.H. 000063346 700__ $$aOosterwijk, E. 000063346 700__ $$aKong, A. 000063346 700__ $$aMayordomo, J.I. 000063346 700__ $$aSverrisdottir, A. 000063346 700__ $$aJonsson, E. 000063346 700__ $$aGudbjartsson, T. 000063346 700__ $$aEinarsson, G.V. 000063346 700__ $$aKiemeney, L.A. 000063346 700__ $$aThorsteinsdottir, U. 000063346 700__ $$aRafnar, T. 000063346 700__ $$aStefansson, K. 000063346 773__ $$g4 (2013), 2776 [7 pp]$$pNATURE COMMUNICATIONS$$tNATURE COMMUNICATIONS$$x2041-1723 000063346 8564_ $$s253690$$uhttps://zaguan.unizar.es/record/63346/files/texto_completo.pdf$$yVersión publicada 000063346 8564_ $$s75712$$uhttps://zaguan.unizar.es/record/63346/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000063346 909CO $$ooai:zaguan.unizar.es:63346$$particulos$$pdriver 000063346 951__ $$a2017-11-28-13:52:23 000063346 980__ $$aARTICLE