000063589 001__ 63589
000063589 005__ 20171221155139.0
000063589 037__ $$aTAZ-TFM-2017-1344
000063589 041__ $$aeng
000063589 1001_ $$aRoche Berdejo, Sandra
000063589 24200 $$aStudy of phospholipid-cholesterol mixtures for mimic cell membranes
000063589 24500 $$aEstudio de mezclas binarias conteniendo dos fosfolípidos y colesterol para la modelización de membranas celulares
000063589 260__ $$aZaragoza$$bUniversidad de Zaragoza$$c2017
000063589 506__ $$aby-nc-sa$$bCreative Commons$$c3.0$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/
000063589 520__ $$aBiological membranes play an important role in life, protecting and separating the cell from the external environment. Since cell membranes are extremely complex systems is necessary to produce mimic cell membranes in order to study how the different components interact with each other as well as with external agents. In this final master project, the Langmuir-Blodgett technique was used to produce mimic cell membranes using two phospholipids, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and cholesterol. The aim of this work is to determine the influence of cholesterol in cell membranes and to analyse the thermodynamic aspects of binary (DMPC-cholesterol, DPPC-cholesterol, DMPC-DPPC) and ternary (cholesterol-DMPC-DPPC) mixed systems. The study of phospholipid monolayers in the presence of cholesterol provides information about the cholesterol role in the stability and the membrane organizations, as well as about the lateral molecular packing in the monolayer. The excess molecular area, the compression modulus, excess Gibbs energy of mixing and excess Helmholtz energy of mixing were calculated as a function of the mole fraction proving the condensing effect of cholesterol in phospholipids bilayers.
000063589 521__ $$aMáster en Materiales Nanoestructurados para Aplicaciones Nanotecnológicas (Nanostructured Materials for Nanotechnology Applications)
000063589 540__ $$aDerechos regulados por licencia Creative Commons
000063589 700__ $$aCea Mingueza, Pilar$$edir.
000063589 700__ $$aMartín Solans, Santiago$$edir.
000063589 7102_ $$aUniversidad de Zaragoza$$bQuímica Física$$cQuímica Física
000063589 8560_ $$f651094@celes.unizar.es
000063589 8564_ $$s1591184$$uhttps://zaguan.unizar.es/record/63589/files/TAZ-TFM-2017-1344.pdf$$yMemoria (eng)
000063589 8564_ $$s827391$$uhttps://zaguan.unizar.es/record/63589/files/TAZ-TFM-2017-1344_ANE.pdf$$yAnexos (eng)
000063589 909CO $$ooai:zaguan.unizar.es:63589$$pdriver$$ptrabajos-fin-master
000063589 950__ $$a
000063589 951__ $$adeposita:2017-12-21
000063589 980__ $$aTAZ$$bTFM$$cCIEN