000065253 001__ 65253
000065253 005__ 20230201140445.0
000065253 0247_ $$2doi$$a10.1186/s12967-018-1380-3
000065253 0248_ $$2sideral$$a104182
000065253 037__ $$aART-2018-104182
000065253 041__ $$aeng
000065253 100__ $$aBaila-Rueda, L.
000065253 245__ $$aAssociation between non-cholesterol sterol concentrations and Achilles tendon thickness in patients with genetic familial hypercholesterolemia
000065253 260__ $$c2018
000065253 5060_ $$aAccess copy available to the general public$$fUnrestricted
000065253 5203_ $$aBackground: Familial hypercholesterolemia (FH) is a genetic disorder that result in abnormally high low-density lipoprotein cholesterol levels, markedly increased risk of coronary heart disease (CHD) and tendon xanthomas (TX). However, the clinical expression is highly variable. TX are present in other metabolic diseases that associate increased sterol concentration. If non-cholesterol sterols are involved in the development of TX in FH has not been analyzed. Methods: Clinical and biochemical characteristics, non-cholesterol sterols concentrations and Aquilles tendon thickness were determined in subjects with genetic FH with (n = 63) and without (n = 40) TX. Student-t test o Mann-Whitney test were used accordingly. Categorical variables were compared using a Chi square test. ANOVA and Kruskal-Wallis tests were performed to multiple independent variables comparison. Post hoc adjusted comparisons were performed with Bonferroni correction when applicable. Correlations of parameters in selected groups were calculated applying the non-parametric Spearman correlation procedure. To identify variables associated with Achilles tendon thickness changes, multiple linear regression were applied. Results: Patients with TX presented higher concentrations of non-cholesterol sterols in plasma than patients without xanthomas (P = 0.006 and 0.034, respectively). Furthermore, there was a significant association between 5a-cholestanol, ß-sitosterol, desmosterol, 24S-hydroxycholesterol and 27-hydroxycholesterol concentrations and Achilles tendon thickness (p = 0.002, 0.012, 0.020, 0.045 and 0.040, respectively). Conclusions: Our results indicate that non-cholesterol sterol concentrations are associated with the presence of TX. Since cholesterol and non-cholesterol sterols are present in the same lipoproteins, further studies would be needed to elucidate their potential role in the development of TX.
000065253 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI15-01983$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI13-02507$$9info:eu-repo/grantAgreement/ES/FIS/PI15-00114
000065253 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000065253 590__ $$a4.098$$b2018
000065253 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b39 / 135 = 0.289$$c2018$$dQ2$$eT1
000065253 592__ $$a1.591$$b2018
000065253 593__ $$aMedicine (miscellaneous)$$c2018$$dQ1
000065253 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2018$$dQ1
000065253 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000065253 700__ $$aLamiquiz-Moneo, I.
000065253 700__ $$0(orcid)0000-0001-9142-0737$$aJarauta, E.$$uUniversidad de Zaragoza
000065253 700__ $$0(orcid)0000-0002-9647-0108$$aMateo-Gallego, R.
000065253 700__ $$0(orcid)0000-0001-6650-8294$$aPerez-Calahorra, S.$$uUniversidad de Zaragoza
000065253 700__ $$aMarco-Benedí, V.
000065253 700__ $$aBea, A.M.
000065253 700__ $$aCenarro, A.
000065253 700__ $$0(orcid)0000-0001-7043-0952$$aCiveira, F.$$uUniversidad de Zaragoza
000065253 7102_ $$11006$$2255$$aUniversidad de Zaragoza$$bDpto. Fisiatría y Enfermería$$cÁrea Enfermería
000065253 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000065253 773__ $$g16, 6 (2018), [9 pp]$$pJournal of Translational Medicine$$tJournal of translational medicine$$x1479-5876
000065253 8564_ $$s1101086$$uhttps://zaguan.unizar.es/record/65253/files/texto_completo.pdf$$yVersión publicada
000065253 8564_ $$s96978$$uhttps://zaguan.unizar.es/record/65253/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000065253 909CO $$ooai:zaguan.unizar.es:65253$$particulos$$pdriver
000065253 951__ $$a2023-02-01-13:46:11
000065253 980__ $$aARTICLE