000065295 001__ 65295
000065295 005__ 20220831095642.0
000065295 0247_ $$2doi$$a10.1371/journal.pone.0189929
000065295 0248_ $$2sideral$$a104287
000065295 037__ $$aART-2017-104287
000065295 041__ $$aeng
000065295 100__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000065295 245__ $$aInfluence of cardiovascular condition on retinal and retinal nerve fiber layer measurements
000065295 260__ $$c2017
000065295 5060_ $$aAccess copy available to the general public$$fUnrestricted
000065295 5203_ $$aObjective To assess changes in the retinal nerve fiber layer (RNFL) and macula in subjects with cardiovascular risk factors or subclinical ischemia. Design Prospective and observational study. Methods A total of 152 healthy men underwent cardiovascular examination, including quantification of subclinical atheroma plaques by artery ultrasound scans, blood analysis, and a complete ophthalmic evaluation, including spectral-domain optical coherence tomography. The variables registered in cardiovascular examination were quantification of classic major risk factors, subclinical atheroma plaques by artery ultrasound scans, and analytical records. The ophthalmic evaluation registered RNFL and macular thickness. Results Mean subject age was 51.27±3.71 years. The 40 subjects without classic cardiovascular risk factors did not show differences in RNFL and macular thicknesses compared with the 112 subjects with at least one risk factor (except in sector 9 that showed higher thicknesses in subjects with 1 risk factor). Comparison between the group of subjects with and without atheroma plaques revealed no differences in RNFL and macular thicknesses. The sub-analysis of subjects with subclinical atheroma plaques in the common carotid artery revealed a significant reduction in central macular thickness in the left eye compared with the right eye (p = 0.016), RNFL in the superior quadrant (p = 0.007), and the 11 o’clock sector (p = 0.020). Comparison between smokers and nonsmokers revealed that smokers had significant thinning of the central macular thickness (p = 0.034), the nasal RNFL quadrant (p = 0.006), and the 3 and 5 o’clock sectors (p = 0.016 and 0.009). Conclusions Classic cardiovascular risk factors do not cause RNFL or macular thickness reduction, but tobacco smoking habit reduces nasal RNFL thickness. Subclinical atherosclerosis in the common carotid artery associates a reduction in central macular and nasal RNFL quadrant thicknesses in the left eye compared with the right eye.
000065295 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000065295 590__ $$a2.766$$b2017
000065295 591__ $$aMULTIDISCIPLINARY SCIENCES$$b15 / 64 = 0.234$$c2017$$dQ1$$eT1
000065295 592__ $$a1.164$$b2017
000065295 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2017$$dQ1
000065295 593__ $$aMedicine (miscellaneous)$$c2017$$dQ1
000065295 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2017$$dQ1
000065295 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000065295 700__ $$aRuiz de Gopegui, E.
000065295 700__ $$aLeón-Latre, M.$$uUniversidad de Zaragoza
000065295 700__ $$0(orcid)0000-0002-6591-0801$$aOtin, S.$$uUniversidad de Zaragoza
000065295 700__ $$aAltemir, I.
000065295 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000065295 700__ $$0(orcid)0000-0002-6745-7668$$aLarrosa, J.M.$$uUniversidad de Zaragoza
000065295 700__ $$aCipres, M.
000065295 700__ $$0(orcid)0000-0002-9887-2629$$aCasasnovas, J.A.$$uUniversidad de Zaragoza
000065295 700__ $$0(orcid)0000-0003-2389-8282$$aPablo, L.E.$$uUniversidad de Zaragoza
000065295 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000065295 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000065295 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000065295 773__ $$g12, 12 (2017), e0189929[14 pp]$$pPLoS One$$tPLoS ONE$$x1932-6203
000065295 8564_ $$s734064$$uhttps://zaguan.unizar.es/record/65295/files/texto_completo.pdf$$yVersión publicada
000065295 8564_ $$s88177$$uhttps://zaguan.unizar.es/record/65295/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000065295 951__ $$a2022-08-31-09:48:15
000065295 980__ $$aARTICLE