65302 20190709135655.0 doi 10.1038/s41467-017-02292-8 sideral 104299 ART-2017-104299 eng Gordon, S.P. Extensive gene content variation in the Brachypodium distachyon pan-genome correlates with population structure 2017 Access copy available to the general public Unrestricted While prokaryotic pan-genomes have been shown to contain many more genes than any individual organism, the prevalence and functional significance of differentially present genes in eukaryotes remains poorly understood. Whole-genome de novo assembly and annotation of 54 lines of the grass Brachypodium distachyon yield a pan-genome containing nearly twice the number of genes found in any individual genome. Genes present in all lines are enriched for essential biological functions, while genes present in only some lines are enriched for conditionally beneficial functions (e.g., defense and development), display faster evolutionary rates, lie closer to transposable elements and are less likely to be syntenic with orthologous genes in other grasses. Our data suggest that differentially present genes contribute substantially to phenotypic variation within a eukaryote species, these genes have a major influence in population genetics, and transposable elements play a key role in pan-genome evolution. info:eu-repo/grantAgreement/ES/DGA/Bioflora info:eu-repo/grantAgreement/ES/DGA/GA-LC-059-2011 info:eu-repo/grantAgreement/ES/MINECO/AGL2013-48756-R info:eu-repo/grantAgreement/ES/MINECO/CGL2012-39953-C02-01 info:eu-repo/grantAgreement/ES/MINECO/CGL2016-79790-P info:eu-repo/grantAgreement/ES/MINECO/CSIC13-4E-2490 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 12.353 2017 MULTIDISCIPLINARY SCIENCES 3 / 64 = 0.047 2017 Q1 T1 6.582 2017 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2017 Q1 Physics and Astronomy (miscellaneous) 2017 Q1 Chemistry (miscellaneous) 2017 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion (orcid)0000-0002-5462-907X Contreras-Moreira, B. Universidad de Zaragoza Woods, D.P. Des Marais, D.L. Burgess, D. Shu, S. Stritt, C. Roulin, A.C. Schackwitz, W. Tyler, L. Martin, J. Lipzen, A. Dochy, N. Phillips, J. Barry, K. Geuten, K. Budak, H. Juenger, T.E. Amasino, R. Caicedo, A.L. Goodstein, D. Davidson, P. Mur, L.A.J. Figueroa, M. Freeling, M. (orcid)0000-0001-7793-5259 Catalan, P. Universidad de Zaragoza Vogel, J.P. 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 5011 063 Universidad de Zaragoza Dpto. CC.Agrar.y Medio Natural Área Botánica 8, 1 (2017), 2184 [13 pp] NATURE COMMUNICATIONS Nature Communications 2041-1723 2395043 http://zaguan.unizar.es/record/65302/files/texto_completo.pdf Versión publicada 82682 http://zaguan.unizar.es/record/65302/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:65302 articulos driver 2019-07-09-12:45:41 ARTICLE