doi:10.1016/j.numecd.2017.10.004engGonzález-Gil, E.M.Cadenas-Sanchez, C.Santabárbara, J.Bueno-Lozano, G.Iglesia, I.González-Gross, M.Molnar, D.Gottrand, F.De Henauw, S.Kafatos, A.Widhalm, K.Manios, Y.Siani, A.Amaro-Gahete, F.Rupérez A.I.Cañada, D.Censi, L.Kersting, M.Dallongeville, J.Marcos, A.Ortega, F.B.Moreno, L.A.Moreno, L.A.Gottrand, F.De Henauw, S.González-Gross, M.Gilbert, C.Kafatos, A.Libersa, C.Castelló, S.Kersting, M.Sjöstrom, M.Molnár, D.Dallongeville, J.Hall, G.Maes, L.Scalfi, L.Meléndez, P.Fleta, J.Casajús, J.A.Rodríguez, G.Tomás, C.Mesana, M.I.Vicente-Rodríguez, G.Villarroya, A.Gil, C.M.Ara, I.Alvira, J.F.Bueno, G.Lázaro, A.Bueno, O.León, J.F.Garagorri, J.M.Bueno, M.Labayen, I.Iglesia, I.Bel Serrat, S.Gracia Marco, L.A.Mouratidou, T.Santaliestra-Pasías, A.González-Gil, E.M.De Miguel-Etayo, P.Julián Almárcegui, C.Miguel-Berges, M.Iguacel, I.Marcos, A.Wärnberg, J.Nova, E.Gómez, S.Díaz, L.E.Romeo, J.Veses, A.Zapatera, B.Pozo, T.Martínez, D.Beghin, L.Gottrand, F.Iliescu, C.Von Berlepsch, J.Sichert-Hellert, W.Koeppen, E.Molnar, D.Erhardt, E.Csernus, K.Török, K.Bokor, S.AngsterNagy, E.Kovács, O.Répasi, J.Codrington, C.Plada, M.Papadaki, A.Sarri, K.Viskadourou, A.Hatzis, C.Kiriakakis, M.Tsibinos, G.Vardavas, C.Sbokos, M.Protoyeraki, E.Fasoulaki, M.Stehle, P.Pietrzik, K.Breidenassel, C.Spinneker, A.Al-Tahan, J.Segoviano, M.Berchtold, A.Bierschbach, C.Blatzheim, E.Schuch, A.Pickert, P.Castillo, M.J.Gutiérrez, Á.Ortega, F.B.Ruiz, J.R.Artero, E.G.España, V.Jiménez-Pavón, D.Chillón, P.Sánchez-Muñoz, C.Cuenca, M.Arcella, D.Azzini, E.Barrison, E.Bevilacqua, N.Buonocore, P.Catasta, G.Censi, L.Ciarapica, D.D''Acapito, P.Ferrari, M.Galfo, M.Le Donne, C.Leclercq, C.Maiani, G.Mauro, B.Mistura, L.Pasquali, A.Piccinelli, R.Polito, A.Roccaldo, R.Spada, R.Sette, S.Zaccaria, M.Vitaglione, P.Montagnese, C.De Bourdeaudhuij, I.De Vriendt, T.Matthys, C.Vereecken, C.de Maeyer, M.Ottevaere, C.Huybrechts, I.Widhalm, K.Phillipp, K.Dietrich, S.Widhalm, K.Phillipp, K.Dietrich, S.Manios, Y.Grammatikaki, E.Bouloubasi, Z.Cook, T.L.Eleutheriou, S.Consta, O.Moschonis, G.Katsaroli, I.Kraniou, G.Papoutsou, S.Keke, D.Petraki, I.Bellou, E.Tanagra, S.Kallianoti, K.Argyropoulou, D.Tsikrika, S.Karaiskos, C.Meirhaeghe, A.Meirhaeghe, A.Ortega, F.B.Hagströmer, M.Wennlöf, A.H.Hallström, L.Patterson, E.Kwak, L.Rizzo, N.Sánchez-Molero, J.Picó, E.Navarro, M.Viadel, B.Carreres, J.E.Merino, G.Sanjuán, R.Lorente, M.Sánchez, M.J.Thomas, S.Allchurch, E.Burgess, P.Astrom, A.Sverkén, A.Broberg, A.Masson, A.Lehoux, C.Brabant, P.Pate, P.Fontaine, L.Sebok, A.Kuti, T.Hegyi, A.Maldonado, C.Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA studyART-2018-104236Background and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-a), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently.2018http://zaguan.unizar.es/record/6558410.1016/j.numecd.2017.10.004http://zaguan.unizar.es/record/65584oai:zaguan.unizar.es:65584info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-007034info:eu-repo/grantAgreement/ES/MINECO/BES-2014-068829info:eu-repo/grantAgreement/ES/MINECO/FJCI-2014-19795info:eu-repo/grantAgreement/ES/MINECO/JCI-2010-07055info:eu-repo/grantAgreement/ES/MINECO/RYC-2011-09011Nutrition, Metabolism and Cardiovascular Diseases 28, 1 (2018), 77-83by-nc-ndhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccess