65584 20230830110636.0 doi 10.1016/j.numecd.2017.10.004 sideral 104236 ART-2018-104236 eng González-Gil, E.M. Universidad de Zaragoza (orcid)0000-0003-2005-8229 Inflammation in metabolically healthy and metabolically abnormal adolescents: The HELENA study 2018 Access copy available to the general public Unrestricted Background and aims Inflammation may influence the cardio-metabolic profile which relates with the risk of chronic diseases. This study aimed to assess the inflammatory status by metabolic health (MH)/body mass index (BMI) category and to assess how inflammatory markers can predict the cardio-metabolic profile in European adolescents, considering BMI. Methods and results A total of 659 adolescents (295 boys) from a cross-sectional European study were included. Adolescents were classified by metabolic health based on age- and sex-specific cut-off points for glucose, blood pressure, triglycerides, high density cholesterol and BMI. C-reactive protein (CRP), tumor necrosis factor alpha (TNF-a), interleukin (IL-6), complement factors (C3, C4) and cell adhesion molecules were assessed. Results Metabolically abnormal (MA) adolescents had higher values of C3 (p < 0.001) and C4 (p = 0.032) compared to those metabolically healthy (MHy). C3 concentrations significantly increased with the deterioration of the metabolic health and BMI (p < 0.001). Adolescents with higher values of CRP had higher probability of being in the overweight/obese-MH group than those allocated in other categories. Finally, high C3 and C4 concentrations increased the probability of having an unfavorable metabolic/BMI status. Conclusions Metabolic/BMI status and inflammatory biomarkers are associated, being the CRP, C3 and C4 the most related inflammatory markers with this condition. C3 and C4 were associated with the cardio-metabolic health consistently. info:eu-repo/grantAgreement/EUR/FP6/FOOD-CT-2005-007034 info:eu-repo/grantAgreement/ES/MINECO/BES-2014-068829 info:eu-repo/grantAgreement/ES/MINECO/FJCI-2014-19795 info:eu-repo/grantAgreement/ES/MINECO/JCI-2010-07055 info:eu-repo/grantAgreement/ES/MINECO/RYC-2011-09011 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.34 2018 CARDIAC & CARDIOVASCULAR SYSTEMS 50 / 135 = 0.37 2018 Q2 T2 NUTRITION & DIETETICS 33 / 85 = 0.388 2018 Q2 T2 ENDOCRINOLOGY & METABOLISM 59 / 145 = 0.407 2018 Q2 T2 1.318 2018 Endocrinology, Diabetes and Metabolism 2018 Q1 Nutrition and Dietetics 2018 Q1 Medicine (miscellaneous) 2018 Q1 Cardiology and Cardiovascular Medicine 2018 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Cadenas-Sanchez, C. Santabárbara, J. Universidad de Zaragoza (orcid)0000-0002-7297-6104 Bueno-Lozano, G. Universidad de Zaragoza (orcid)0000-0002-0902-387X Iglesia, I. (orcid)0000-0002-2219-3646 González-Gross, M. Molnar, D. Gottrand, F. De Henauw, S. Kafatos, A. Widhalm, K. Manios, Y. Siani, A. Amaro-Gahete, F. Rupérez A.I. Universidad de Zaragoza (orcid)0000-0002-3850-8235 Cañada, D. Censi, L. Kersting, M. Dallongeville, J. Marcos, A. Ortega, F.B. Moreno, L.A. Universidad de Zaragoza (orcid)0000-0003-0454-653X Moreno, L.A. Gottrand, F. De Henauw, S. González-Gross, M. Gilbert, C. Kafatos, A. Libersa, C. Castelló, S. Kersting, M. Sjöstrom, M. Molnár, D. Dallongeville, J. Hall, G. Maes, L. Scalfi, L. Meléndez, P. Fleta, J. Casajús, J.A. Rodríguez, G. Tomás, C. Mesana, M.I. Vicente-Rodríguez, G. Villarroya, A. Gil, C.M. Ara, I. Alvira, J.F. Bueno, G. Lázaro, A. Bueno, O. León, J.F. Garagorri, J.M. Bueno, M. Labayen, I. Iglesia, I. Bel Serrat, S. Gracia Marco, L.A. Mouratidou, T. Santaliestra-Pasías, A. González-Gil, E.M. De Miguel-Etayo, P. Julián Almárcegui, C. Miguel-Berges, M. Iguacel, I. Marcos, A. Wärnberg, J. Nova, E. Gómez, S. Díaz, L.E. Romeo, J. Veses, A. Zapatera, B. Pozo, T. Martínez, D. Beghin, L. Gottrand, F. Iliescu, C. Von Berlepsch, J. Sichert-Hellert, W. Koeppen, E. Molnar, D. Erhardt, E. Csernus, K. Török, K. Bokor, S. Angster Nagy, E. Kovács, O. Répasi, J. Codrington, C. Plada, M. Papadaki, A. Sarri, K. Viskadourou, A. Hatzis, C. Kiriakakis, M. Tsibinos, G. Vardavas, C. Sbokos, M. Protoyeraki, E. Fasoulaki, M. Stehle, P. Pietrzik, K. Breidenassel, C. Spinneker, A. Al-Tahan, J. Segoviano, M. Berchtold, A. Bierschbach, C. Blatzheim, E. Schuch, A. Pickert, P. Castillo, M.J. Gutiérrez, Á. Ortega, F.B. Ruiz, J.R. Artero, E.G. España, V. Jiménez-Pavón, D. Chillón, P. Sánchez-Muñoz, C. Cuenca, M. Arcella, D. Azzini, E. Barrison, E. Bevilacqua, N. Buonocore, P. Catasta, G. Censi, L. Ciarapica, D. D''Acapito, P. Ferrari, M. Galfo, M. Le Donne, C. Leclercq, C. Maiani, G. Mauro, B. Mistura, L. Pasquali, A. Piccinelli, R. Polito, A. Roccaldo, R. Spada, R. Sette, S. Zaccaria, M. Vitaglione, P. Montagnese, C. De Bourdeaudhuij, I. De Vriendt, T. Matthys, C. Vereecken, C. de Maeyer, M. Ottevaere, C. Huybrechts, I. Widhalm, K. Phillipp, K. Dietrich, S. Widhalm, K. Phillipp, K. Dietrich, S. Manios, Y. Grammatikaki, E. Bouloubasi, Z. Cook, T.L. Eleutheriou, S. Consta, O. Moschonis, G. Katsaroli, I. Kraniou, G. Papoutsou, S. Keke, D. Petraki, I. Bellou, E. Tanagra, S. Kallianoti, K. Argyropoulou, D. Tsikrika, S. Karaiskos, C. Meirhaeghe, A. Meirhaeghe, A. Ortega, F.B. Hagströmer, M. Wennlöf, A.H. Hallström, L. Patterson, E. Kwak, L. Rizzo, N. Sánchez-Molero, J. Picó, E. Navarro, M. Viadel, B. Carreres, J.E. Merino, G. Sanjuán, R. Lorente, M. Sánchez, M.J. Thomas, S. Allchurch, E. Burgess, P. Astrom, A. Sverkén, A. Broberg, A. Masson, A. Lehoux, C. Brabant, P. Pate, P. Fontaine, L. Sebok, A. Kuti, T. Hegyi, A. Maldonado, C. 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1008 615 Universidad de Zaragoza Dpto. Microb.Med.Pr.,Sal.Públ. Área Medic.Prevent.Salud Públ. 1010 670 Universidad de Zaragoza Dpto. Pediatría Radiol.Med.Fís Área Pediatría 28, 1 (2018), 77-83 NMCD, Nutr. Metab. Cardiovasc. Dis. Nutrition, Metabolism and Cardiovascular Diseases 0939-4753 235905 http://zaguan.unizar.es/record/65584/files/texto_completo.pdf Postprint 64128 http://zaguan.unizar.es/record/65584/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:65584 articulos driver 2023-08-30-10:57:30 ARTICLE