000069162 001__ 69162
000069162 005__ 20190709135441.0
000069162 0247_ $$2doi$$a10.1016/j.actatropica.2017.02.031
000069162 0248_ $$2sideral$$a98131
000069162 037__ $$aART-2017-98131
000069162 041__ $$aeng
000069162 100__ $$aFlores, B.J.
000069162 245__ $$aA cross-sectional epidemiological study of domestic animals related to human leptospirosis cases in Nicaragua
000069162 260__ $$c2017
000069162 5060_ $$aAccess copy available to the general public$$fUnrestricted
000069162 5203_ $$aLeptospirosis is one of the most extended zoonosis worldwide and humans become infected most commonly through contact with the urine of carrier animals, either directly or via contaminated water or soil. The aim in this study was to analyse the epidemiological behaviour of Leptospira spp., from domestic animals around the sites of human leptospirosis cases in Nicaragua, from 2007 through 2013. We report the results of a cross-sectional epidemiological study with a non-probability sampling of blood (n = 3050) and urine (n = 299) from Domestic Animals (DA) around the sites of human leptospirosis cases in Nicaragua. We analysed data obtained through Microscopic Agglutination Test (MAT), in-vitro culture, real time PCR and sequencing of lfb1 locus. Frequencies of 30.31% (95% CI: 28.66–31.95) and 15.38% (95% CI: 11.12–19.64) were obtained from serological test and from in-vitro culture, respectively. Although similar frequencies from serology test (P = 0.05) were found in DA species, in-vitro culture frequencies were significantly higher from bovine, equine and sheep (P < 0.05) in comparison with swine and canine species. Ten serogroups of pathogenic Leptospira spp. were encountered, with the highest presence of Icterohaemorrhagiae serogroup 34.65% (95% CI: 29.35–39.94). We identified 7 samples homologous to L. interrogans species Pyrogenes serovar and 3 samples as L. noguchii Louisiana or Panama serovars by analysis of lfb1 sequences. We were able to establish a temporal and spatial correlation from DA and cumulative incidence of human cases. Therefore an effective epidemiological surveillance should be implemented with a specific control program toward DA in order to reduce human leptospirosis incidence.
000069162 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000069162 590__ $$a2.509$$b2017
000069162 591__ $$aTROPICAL MEDICINE$$b8 / 20 = 0.4$$c2017$$dQ2$$eT2
000069162 591__ $$aPARASITOLOGY$$b16 / 37 = 0.432$$c2017$$dQ2$$eT2
000069162 592__ $$a1.052$$b2017
000069162 593__ $$aInsect Science$$c2017$$dQ1
000069162 593__ $$aVeterinary (miscellaneous)$$c2017$$dQ1
000069162 593__ $$aParasitology$$c2017$$dQ2
000069162 593__ $$aInfectious Diseases$$c2017$$dQ2
000069162 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000069162 700__ $$0(orcid)0000-0001-5095-3289$$aPérez-Sánchez, T.$$uUniversidad de Zaragoza
000069162 700__ $$aFuertes, H.
000069162 700__ $$aSheleby-Elías, J.
000069162 700__ $$0(orcid)0000-0001-5422-1122$$aMúzquiz, J.L.$$uUniversidad de Zaragoza
000069162 700__ $$aJirón, W.
000069162 700__ $$aDuttmann, C.
000069162 700__ $$0(orcid)0000-0002-4121-8087$$aHalaihel, N.$$uUniversidad de Zaragoza
000069162 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000069162 773__ $$g170 (2017), 79-84$$pActa Trop.$$tACTA TROPICA$$x0001-706X
000069162 8564_ $$s259915$$uhttps://zaguan.unizar.es/record/69162/files/texto_completo.pdf$$yPostprint
000069162 8564_ $$s42135$$uhttps://zaguan.unizar.es/record/69162/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000069162 909CO $$ooai:zaguan.unizar.es:69162$$pdriver$$particulos
000069162 951__ $$a2019-07-09-11:36:22
000069162 980__ $$aARTICLE