000069622 001__ 69622
000069622 005__ 20190709135527.0
000069622 0247_ $$2doi$$a10.1007/s11095-017-2146-y
000069622 0248_ $$2sideral$$a98419
000069622 037__ $$aART-2017-98419
000069622 041__ $$aeng
000069622 100__ $$0(orcid)0000-0003-2585-0346$$aAlbisa, A.$$uUniversidad de Zaragoza
000069622 245__ $$aPreparation of Drug-Loaded PLGA-PEG Nanoparticles by Membrane-Assisted Nanoprecipitation
000069622 260__ $$c2017
000069622 5060_ $$aAccess copy available to the general public$$fUnrestricted
000069622 5203_ $$aPurpose: The aim of this work is to develop a scalable continuous system suitable for the formulation of polymeric nanoparticles using membrane-assisted nanoprecipitation. One of the hurdles to overcome in the use of nanostructured materials as drug delivery vectors is their availability at industrial scale. Innovation in process technology is required to translate laboratory production into mass production while preserving their desired nanoscale characteristics. Methods: Membrane-assisted nanoprecipitation has been used for the production of Poly(D, L lactide-co-glycolide)-co-poly ethylene glycol] diblock) (PLGA-PEG) nanoparticles using a pulsed back-and-forward flow arrangement. Tubular Shirasu porous glass membranes (SPG) with pore diameters of 1 and 0.2 µm were used to control the mixing process during the nanoprecipitation reaction. Results: The size of the resulting PLGA-PEG nanoparticles could be readily tuned in the range from 250 to 400 nm with high homogeneity (PDI lower than 0.2) by controlling the dispersed phase volume/continuous phase volume ratio. Dexamethasone was successfully encapsulated in a continuous process, achieving an encapsulation efficiency and drug loading efficiency of 50% and 5%, respectively. The dexamethasone was released from the nanoparticles following Fickian kinetics. Conclusions: The method allowed to produce polymeric nanoparticles for drug delivery with a high productivity, reproducibility and easy scalability.
000069622 536__ $$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM$$9info:eu-repo/grantAgreement/EC/FP7/321642/EU/Development of a microfluidic platform to produce nanomaterials and assessment on new nanotechnology applications/PLATFORM2NANO
000069622 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000069622 590__ $$a3.335$$b2017
000069622 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b61 / 171 = 0.357$$c2017$$dQ2$$eT2
000069622 591__ $$aPHARMACOLOGY & PHARMACY$$b74 / 261 = 0.284$$c2017$$dQ2$$eT1
000069622 592__ $$a1.077$$b2017
000069622 593__ $$aBiotechnology$$c2017$$dQ1
000069622 593__ $$aOrganic Chemistry$$c2017$$dQ1
000069622 593__ $$aPharmaceutical Science$$c2017$$dQ1
000069622 593__ $$aPharmacology$$c2017$$dQ2
000069622 593__ $$aPharmacology (medical)$$c2017$$dQ2
000069622 593__ $$aMolecular Medicine$$c2017$$dQ2
000069622 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000069622 700__ $$aPiacentini, E.
000069622 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, V.$$uUniversidad de Zaragoza
000069622 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, M.$$uUniversidad de Zaragoza
000069622 700__ $$0(orcid)0000-0002-8701-9745$$aSantamaria, J.$$uUniversidad de Zaragoza
000069622 700__ $$aGiorno, L.
000069622 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000069622 773__ $$g34, 6 (2017), 1296-1308$$pPharm. res.$$tPHARMACEUTICAL RESEARCH$$x0724-8741
000069622 8564_ $$s1751893$$uhttps://zaguan.unizar.es/record/69622/files/texto_completo.pdf$$yPostprint
000069622 8564_ $$s39644$$uhttps://zaguan.unizar.es/record/69622/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000069622 909CO $$ooai:zaguan.unizar.es:69622$$particulos$$pdriver
000069622 951__ $$a2019-07-09-12:00:26
000069622 980__ $$aARTICLE