000069683 001__ 69683
000069683 005__ 20190529115239.0
000069683 0247_ $$2doi$$a10.22489/CinC.2017.224-267
000069683 0248_ $$2sideral$$a105206
000069683 037__ $$aART-2017-105206
000069683 041__ $$aeng
000069683 100__ $$0(orcid)0000-0003-4130-5866$$aRamírez$$uUniversidad de Zaragoza
000069683 245__ $$aComparison of ECG T-wave Duration and Morphology Restitution Markers for Sudden Cardiac Death Prediction in Chronic Heart Failure
000069683 260__ $$c2017
000069683 5060_ $$aAccess copy available to the general public$$fUnrestricted
000069683 5203_ $$aAn index of T-wave morphology restitution, TMR, has previously shown to be a sudden cardiac death (SCD) predictor in a population of chronic heart failure (CHF) patients. The aim of this study is to compare the predictive value of TMR, T-wave width restitution (TWR), Tpeak-to-end (Tpe) morphology restitution (TpeMR) and Tpe duration restitution (T peR) indices in the same CHF population. Holter ECG recordings from 651 CHF patients of the MUSIC study, including SCD victims and survivors, were analyzed. TMR was significantly correlated with T W R (¿=0.66), T peM R (¿=0.70) and T peR (¿=0.42). SCD victims showed significantly higher values of TMR, TWR and TpeMR than the rest of patients, with T M R being the index most strongly associated with SCD (p=0.002, p=0.006 and p=0.011, respectively). T peR values were only borderline significantly higher in SCD victims (p=0.061). Univariate Cox analysis showed that T M R was the restitution index with the strongest predictive value (hazard ratio (HR) of 1.466, p<0.001), followed by TWR (HR of 1.295, p=0.005), TpeR (HR of 1.297, p=0.004) and T peM R (HR of 1.164, p=0.020). In conclusion, considering the predictive value of the four Twave restitution indices, TMR is the preferred index for SCD risk stratification, followed by TpeMR. However, the marker TWR could also be used for SCD prediction when computational efficiency is an issue.
000069683 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/DPI2016-75458-R$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE$$9info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE$$9info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R
000069683 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000069683 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000069683 700__ $$aJulia
000069683 700__ $$0(orcid)0000-0002-1960-407X$$aOrini$$uUniversidad de Zaragoza
000069683 700__ $$0(orcid)0000-0003-3434-9254$$aMichele$$uUniversidad de Zaragoza
000069683 700__ $$aPueyo
000069683 700__ $$aEsther
000069683 700__ $$aLaguna
000069683 700__ $$aPablo
000069683 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000069683 773__ $$g44 (2017), [4 pp]$$pComput. cardiol.$$tComputing in Cardiology$$x2325-8861
000069683 8564_ $$s301946$$uhttps://zaguan.unizar.es/record/69683/files/texto_completo.pdf$$yPostprint
000069683 8564_ $$s113379$$uhttps://zaguan.unizar.es/record/69683/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000069683 909CO $$ooai:zaguan.unizar.es:69683$$particulos$$pdriver
000069683 951__ $$a2019-05-29-11:44:26
000069683 980__ $$aARTICLE