69683 20190529115239.0 doi 10.22489/CinC.2017.224-267 sideral 105206 ART-2017-105206 eng (orcid)0000-0003-4130-5866 Ramírez Universidad de Zaragoza Comparison of ECG T-wave Duration and Morphology Restitution Markers for Sudden Cardiac Death Prediction in Chronic Heart Failure 2017 Access copy available to the general public Unrestricted An index of T-wave morphology restitution, TMR, has previously shown to be a sudden cardiac death (SCD) predictor in a population of chronic heart failure (CHF) patients. The aim of this study is to compare the predictive value of TMR, T-wave width restitution (TWR), Tpeak-to-end (Tpe) morphology restitution (TpeMR) and Tpe duration restitution (T peR) indices in the same CHF population. Holter ECG recordings from 651 CHF patients of the MUSIC study, including SCD victims and survivors, were analyzed. TMR was significantly correlated with T W R (¿=0.66), T peM R (¿=0.70) and T peR (¿=0.42). SCD victims showed significantly higher values of TMR, TWR and TpeMR than the rest of patients, with T M R being the index most strongly associated with SCD (p=0.002, p=0.006 and p=0.011, respectively). T peR values were only borderline significantly higher in SCD victims (p=0.061). Univariate Cox analysis showed that T M R was the restitution index with the strongest predictive value (hazard ratio (HR) of 1.466, p<0.001), followed by TWR (HR of 1.295, p=0.005), TpeR (HR of 1.297, p=0.004) and T peM R (HR of 1.164, p=0.020). In conclusion, considering the predictive value of the four Twave restitution indices, TMR is the preferred index for SCD risk stratification, followed by TpeMR. However, the marker TWR could also be used for SCD prediction when computational efficiency is an issue. info:eu-repo/grantAgreement/ES/MINECO/DPI2016-75458-R This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 638284-MODELAGE info:eu-repo/grantAgreement/EC/H2020/638284/EU/Is your heart aging well? A systems biology approach to characterize cardiac aging from the cell to the body surface/MODELAGE info:eu-repo/grantAgreement/ES/MINECO/TIN2013-41998-R info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Julia (orcid)0000-0002-1960-407X Orini Universidad de Zaragoza (orcid)0000-0003-3434-9254 Michele Universidad de Zaragoza Pueyo Esther Laguna Pablo 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 44 (2017), [4 pp] Comput. cardiol. Computing in Cardiology 2325-8861 301946 http://zaguan.unizar.es/record/69683/files/texto_completo.pdf Postprint 113379 http://zaguan.unizar.es/record/69683/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:69683 articulos driver 2019-05-29-11:44:26 ARTICLE